clozapine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
psychoactive 722 5786-21-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • clozapine
  • asaleptin
  • azaleptine
  • clozapin
  • clozaril
  • fazaclo
  • klozapol
  • leponex
A tricylic dibenzodiazepine, classified as an atypical antipsychotic agent. It binds several types of central nervous system receptors, and displays a unique pharmacological profile. Clozapine is a serotonin antagonist, with strong binding to 5-HT 2A/2C receptor subtype. It also displays strong affinity to several dopaminergic receptors, but shows only weak antagonism at the dopamine D2 receptor, a receptor commonly thought to modulate neuroleptic activity. Agranulocytosis is a major adverse effect associated with administration of this agent.
  • Molecular weight: 326.83
  • Formula: C18H19ClN4
  • CLOGP: 3.56
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 1
  • TPSA: 30.87
  • ALOGS: -3.25
  • ROTB: 0
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.30 g O
0.30 g P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.01 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 0.50 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 45.90 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 55 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 1.60 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 2.50 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.06 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 10 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Sept. 26, 1989 FDA NOVARTIS

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hospitalisation 4856.78 16.33 2399 90275 82682 63313666
Neutropenia 4824.27 16.33 3055 89619 171950 63224398
Granulocytopenia 2978.62 16.33 824 91850 4848 63391500
Neutrophil count increased 2941.82 16.33 1050 91624 15477 63380871
Neutrophilia 2819.06 16.33 748 91926 3658 63392690
White blood cell count increased 2482.26 16.33 1273 91401 47288 63349060
Death 2472.87 16.33 2874 89800 371507 63024841
Antipsychotic drug level increased 1825.97 16.33 504 92170 2931 63393417
Salivary hypersecretion 1314.04 16.33 474 92200 7192 63389156
Psychotic disorder 1194.86 16.33 633 92041 25079 63371269
White blood cell count decreased 1117.24 16.33 1187 91487 137917 63258431
Neutrophil count decreased 1108.74 16.33 802 91872 55604 63340744
Sedation 1096.20 16.33 691 91983 38118 63358230
Agranulocytosis 1020.87 16.33 566 92108 24568 63371780
Differential white blood cell count abnormal 1006.51 16.33 233 92441 553 63395795
Mental impairment 986.07 16.33 459 92215 13692 63382656
Anosognosia 810.53 16.33 265 92409 2931 63393417
Myocarditis 772.78 16.33 352 92322 9973 63386375
Leukopenia 766.79 16.33 740 91934 76550 63319798
Blood prolactin abnormal 735.42 16.33 244 92430 2835 63393513
Disturbance in social behaviour 707.13 16.33 253 92421 3740 63392608
Dystonia 675.26 16.33 352 92322 13467 63382881
Pain 663.85 16.33 138 92536 740490 62655858
Sexual dysfunction 663.43 16.33 247 92427 4112 63392236
Dyskinesia 648.94 16.33 464 92210 31538 63364810
Metabolic disorder 630.43 16.33 266 92408 6237 63390111
Schizophrenia 617.25 16.33 298 92376 9654 63386694
Treatment noncompliance 606.85 16.33 474 92200 36851 63359497
Platelet count increased 590.97 16.33 351 92323 17360 63378988
Arthralgia 576.86 16.33 76 92598 569634 62826714
Schizoaffective disorder 542.67 16.33 202 92472 3360 63392988
Drug level increased 539.16 16.33 363 92311 22373 63373975
Suicide attempt 527.71 16.33 542 92132 60376 63335972
Rash 526.27 16.33 93 92581 560778 62835570
Personality change 522.64 16.33 238 92436 6735 63389613
Electrocardiogram QT prolonged 512.67 16.33 528 92146 59002 63337346
Hallucination, auditory 510.14 16.33 285 92389 12539 63383809
Fatigue 499.51 16.33 345 92329 887683 62508665
Headache 483.37 16.33 162 92512 633079 62763269
Mental disorder 482.68 16.33 357 92317 25562 63370786
Nausea 458.16 16.33 349 92325 854122 62542226
Neuroleptic malignant syndrome 458.07 16.33 260 92414 11796 63384552
Antipsychotic drug level above therapeutic 440.87 16.33 128 92546 915 63395433
Delusion 424.10 16.33 247 92427 11770 63384578
Alopecia 406.64 16.33 21 92653 337515 63058833
Pruritus 404.46 16.33 33 92641 361420 63034928
Haemoglobin decreased 391.40 16.33 735 91939 144750 63251598
Tachycardia 380.78 16.33 646 92028 117510 63278838
Leukocytosis 373.81 16.33 307 92367 25628 63370720
Eosinophil count decreased 362.42 16.33 132 92542 2058 63394290
Joint swelling 360.82 16.33 32 92642 327634 63068714
Catatonia 355.15 16.33 159 92515 4318 63392030
Rheumatoid arthritis 344.69 16.33 5 92669 253814 63142534
Diarrhoea 331.09 16.33 335 92339 715031 62681317
Abdominal discomfort 321.30 16.33 44 92630 320841 63075507
Drug interaction 319.15 16.33 892 91782 228239 63168109
Swelling 316.83 16.33 22 92652 275356 63120992
Drug hypersensitivity 314.89 16.33 41 92633 310646 63085702
Antipsychotic drug level decreased 309.08 16.33 77 92597 276 63396072
Psychiatric decompensation 294.97 16.33 101 92573 1300 63395048
Overdose 294.06 16.33 569 92105 114509 63281839
Troponin increased 292.47 16.33 183 92491 9938 63386410
Arthropathy 281.37 16.33 15 92659 234777 63161571
Drug intolerance 276.54 16.33 57 92617 308604 63087744
Sinusitis 273.11 16.33 14 92660 226639 63169709
Peripheral swelling 272.08 16.33 34 92640 265908 63130440
Pain in extremity 264.40 16.33 78 92596 331408 63064940
Sinus tachycardia 254.83 16.33 240 92434 24028 63372320
Hypersensitivity 254.15 16.33 58 92616 292627 63103721
Systemic lupus erythematosus 248.28 16.33 14 92660 208904 63187444
Extrapyramidal disorder 236.15 16.33 178 92496 13106 63383242
C-reactive protein increased 233.03 16.33 461 92213 94246 63302102
Somnolence 219.11 16.33 665 92009 178020 63218328
Blood glucose increased 216.14 16.33 416 92258 83340 63313008
Paranoia 213.19 16.33 159 92515 11520 63384828
Mean cell haemoglobin decreased 211.13 16.33 117 92557 5062 63391286
Pre-existing disease 204.83 16.33 49 92625 141 63396207
Nasopharyngitis 202.33 16.33 60 92614 254197 63142151
Therapeutic product effect decreased 201.71 16.33 23 92651 193164 63203184
Mean cell haemoglobin concentration decreased 199.59 16.33 100 92574 3512 63392836
Living in residential institution 196.42 16.33 59 92615 481 63395867
Antipsychotic drug level below therapeutic 195.50 16.33 52 92622 256 63396092
Back pain 188.30 16.33 75 92599 264070 63132278
Monocyte count increased 185.66 16.33 123 92551 7370 63388978
Urticaria 185.58 16.33 15 92659 165787 63230561
Dyspnoea 184.30 16.33 436 92238 660877 62735471
Treatment failure 181.82 16.33 35 92639 199008 63197340
Discomfort 179.65 16.33 18 92656 167356 63228992
Stomatitis 179.20 16.33 5 92669 138720 63257628
Eosinophil count increased 177.96 16.33 139 92535 10789 63385559
Eosinophilia 176.45 16.33 191 92483 22565 63373783
Agitation 174.42 16.33 313 92361 59444 63336904
Wound 174.08 16.33 18 92656 163245 63233103
Injection site pain 170.22 16.33 4 92670 129796 63266552
Blister 162.95 16.33 6 92668 129808 63266540
Refusal of examination 161.43 16.33 41 92633 162 63396186
Lung neoplasm malignant 161.43 16.33 170 92504 19463 63376885
Aggression 161.19 16.33 185 92489 23313 63373035
Chronic obstructive pulmonary disease 157.59 16.33 308 92366 62378 63333970
Lymphocyte count decreased 153.99 16.33 205 92469 30052 63366296
Pleurothotonus 153.86 16.33 62 92612 1287 63395061
Haematocrit decreased 153.74 16.33 235 92439 39105 63357243
Erythema 152.09 16.33 35 92639 175716 63220632
Abdominal pain upper 148.09 16.33 58 92616 206386 63189962
Hypoaesthesia 146.78 16.33 33 92641 168360 63227988
Red cell distribution width increased 146.22 16.33 122 92552 10402 63385946
Lymphocyte count increased 146.13 16.33 80 92594 3378 63392970
Abnormal behaviour 145.81 16.33 168 92506 21258 63375090
Psychotic symptom 141.82 16.33 61 92613 1500 63394848
On and off phenomenon 141.81 16.33 64 92610 1771 63394577
Akathisia 141.76 16.33 113 92561 9033 63387315
Mean cell volume decreased 140.95 16.33 82 92592 3896 63392452
General physical condition abnormal 140.68 16.33 84 92590 4190 63392158
Drooling 140.42 16.33 81 92593 3787 63392561
Hyperprolactinaemia 137.15 16.33 80 92594 3820 63392528
Neoplasm malignant 136.39 16.33 192 92482 29669 63366679
Impaired healing 135.07 16.33 3 92671 102539 63293809
Red blood cell count decreased 133.07 16.33 224 92450 40421 63355927
Hepatic enzyme increased 132.23 16.33 65 92609 202263 63194085
Drug ineffective 127.20 16.33 950 91724 1043815 62352533
Suicidal ideation 125.66 16.33 280 92394 62141 63334207
Contraindicated product administered 124.94 16.33 82 92592 217566 63178782
Muscle rigidity 123.14 16.33 115 92559 11385 63384963
Electroencephalogram abnormal 123.02 16.33 73 92601 3599 63392749
Terminal state 122.63 16.33 62 92612 2220 63394128
Neuropathy peripheral 122.53 16.33 12 92662 113655 63282693
Paraesthesia 121.26 16.33 39 92635 156927 63239421
Aspiration 121.01 16.33 111 92563 10740 63385608
Therapy interrupted 120.00 16.33 189 92485 32266 63364082
Disease progression 119.96 16.33 18 92656 122740 63273608
Blood prolactin increased 118.30 16.33 70 92604 3433 63392915
Cough 116.55 16.33 154 92520 292589 63103759
Pneumonia aspiration 115.26 16.33 192 92482 34348 63362000
Choking 113.97 16.33 103 92571 9776 63386572
Obsessive-compulsive disorder 113.75 16.33 72 92602 3988 63392360
Intestinal obstruction 112.94 16.33 179 92495 30720 63365628
Neutrophil count abnormal 111.53 16.33 63 92611 2829 63393519
Asthenia 110.50 16.33 248 92426 383356 63012992
Faecaloma 110.21 16.33 92 92582 7849 63388499
Haemoglobin increased 108.04 16.33 67 92607 3579 63392769
Delirium 107.72 16.33 232 92442 50309 63346039
Generalised tonic-clonic seizure 107.31 16.33 169 92505 28847 63367501
Coronavirus infection 105.44 16.33 70 92604 4208 63392140
Breast cancer 105.31 16.33 224 92450 48159 63348189
Arthritis 104.51 16.33 21 92653 115900 63280448
Musculoskeletal pain 104.19 16.33 8 92666 92269 63304079
Migraine 103.67 16.33 14 92660 103332 63293016
Fibromyalgia 103.46 16.33 3 92671 80417 63315931
Urinary incontinence 101.57 16.33 174 92500 31840 63364508
Contusion 101.40 16.33 46 92628 149998 63246350
Hallucination 100.49 16.33 237 92437 54580 63341768
Dementia 99.74 16.33 130 92544 18664 63377684
Blood creatine phosphokinase increased 98.67 16.33 167 92507 30263 63366085
Intentional product use issue 98.37 16.33 32 92642 127860 63268488
Intentional self-injury 98.32 16.33 152 92522 25535 63370813
Wrong patient received product 95.87 16.33 52 92622 2155 63394193
Decreased appetite 94.95 16.33 137 92537 250915 63145433
Troponin T increased 94.58 16.33 43 92631 1211 63395137
COVID-19 93.10 16.33 369 92305 112734 63283614
Malignant neoplasm progression 93.06 16.33 7 92667 82114 63314234
Muscle spasms 92.09 16.33 57 92617 156093 63240255
Acute psychosis 91.99 16.33 53 92621 2472 63393876
Orthostatic hypotension 91.25 16.33 178 92496 35982 63360366
Irritable bowel syndrome 90.68 16.33 8 92666 82404 63313944
Mean cell volume increased 89.69 16.33 59 92615 3492 63392856
Psoriasis 89.10 16.33 11 92663 86946 63309402
Psychiatric symptom 88.44 16.33 68 92606 5155 63391193
Metabolic syndrome 87.84 16.33 44 92630 1544 63394804
Myoclonus 87.71 16.33 112 92562 15756 63380592
Febrile neutropenia 87.02 16.33 32 92642 118417 63277931
Mutism 86.75 16.33 44 92630 1586 63394762
Maternal exposure during pregnancy 86.28 16.33 117 92557 219945 63176403
Sopor 84.61 16.33 131 92543 22033 63374315
Oculogyric crisis 84.50 16.33 44 92630 1677 63394671
Myalgia 84.33 16.33 55 92619 146474 63249874
Toxicity to various agents 83.40 16.33 632 92042 246618 63149730
Osteoarthritis 82.42 16.33 19 92655 95324 63301024
Diabetes mellitus 82.13 16.33 222 92452 55588 63340760
Circulatory collapse 81.43 16.33 128 92546 21810 63374538
Mania 80.84 16.33 95 92579 12272 63384076
Pericardial effusion 80.80 16.33 152 92522 29906 63366442
Flushing 80.72 16.33 8 92666 75079 63321269
Parkinsonism 79.83 16.33 87 92587 10352 63385996
Pneumonia 78.10 16.33 1013 91661 455754 62940594
Gastrointestinal disorder 77.25 16.33 48 92626 131191 63265157
Polyserositis 76.65 16.33 27 92647 380 63395968
Stoma site discharge 76.02 16.33 40 92634 1558 63394790
Lung cancer metastatic 75.41 16.33 47 92627 2533 63393815
Constipation 74.17 16.33 572 92102 224371 63171977
Tardive dyskinesia 74.16 16.33 76 92598 8426 63387922
Musculoskeletal stiffness 73.53 16.33 97 92577 184521 63211827
Platelet count decreased 73.45 16.33 350 92324 115772 63280576
Nasal congestion 73.26 16.33 6 92668 65654 63330694
Malaise 71.29 16.33 923 91751 415031 62981317
Enuresis 70.52 16.33 45 92629 2528 63393820
Epistaxis 70.27 16.33 11 92663 72714 63323634
Gastrointestinal hypomotility 68.92 16.33 33 92641 1048 63395300
Refusal of treatment by patient 68.75 16.33 60 92614 5437 63390911
Off label use 68.66 16.33 642 92032 673820 62722528
Anaphylactic reaction 68.61 16.33 8 92666 66092 63330256
Blood alkaline phosphatase increased 68.39 16.33 176 92498 42791 63353557
Rash pruritic 68.03 16.33 5 92669 59794 63336554
Electrocardiogram abnormal 67.60 16.33 75 92599 9104 63387244
Electrocardiogram T wave abnormal 67.57 16.33 43 92631 2404 63393944
Monocyte count decreased 67.46 16.33 41 92633 2112 63394236
Intentional overdose 66.79 16.33 249 92425 73903 63322445
Dyspepsia 66.46 16.33 33 92641 102163 63294185
Benign ethnic neutropenia 66.37 16.33 12 92662 0 63396348
Knee arthroplasty 66.34 16.33 3 92671 54203 63342145
Oedema peripheral 66.27 16.33 109 92565 189402 63206946
Ileus paralytic 65.81 16.33 54 92620 4497 63391851
Haematocrit increased 64.54 16.33 41 92633 2285 63394063
Herpes zoster 64.53 16.33 20 92654 82442 63313906
Inappropriate schedule of product administration 64.03 16.33 36 92638 103929 63292419
Freezing phenomenon 63.83 16.33 33 92641 1239 63395109
Insurance issue 63.21 16.33 60 92614 6061 63390287
Muscle injury 62.87 16.33 10 92664 65335 63331013
Impaired self-care 62.19 16.33 37 92637 1833 63394515
Epilepsy 62.02 16.33 128 92546 26937 63369411
Posture abnormal 61.97 16.33 40 92634 2292 63394056
Bradykinesia 61.64 16.33 55 92619 5133 63391215
Rebound psychosis 60.82 16.33 19 92655 179 63396169
Lower respiratory tract infection 60.63 16.33 365 92309 131942 63264406
Sinus rhythm 60.32 16.33 28 92646 828 63395520
Hypothermia 60.05 16.33 86 92588 13495 63382853
Hypertension 59.93 16.33 208 92466 279095 63117253
Wheezing 59.02 16.33 33 92641 95562 63300786
Stoma site erythema 58.71 16.33 31 92643 1216 63395132
Blood urea decreased 58.47 16.33 39 92635 2363 63393985
Chest discomfort 58.36 16.33 45 92629 109924 63286424
Electrocardiogram T wave inversion 58.24 16.33 45 92629 3436 63392912
Stoma site irritation 58.02 16.33 19 92655 211 63396137
Blood pressure increased 57.79 16.33 92 92582 161970 63234378
Cardiomyopathy 57.66 16.33 97 92577 17487 63378861
Oedema 57.03 16.33 36 92638 97586 63298762
Hot flush 56.18 16.33 5 92669 51154 63345194
Mucosal inflammation 56.14 16.33 3 92671 46925 63349423
Weight decreased 55.51 16.33 212 92462 276586 63119762
Loss of personal independence in daily activities 55.31 16.33 37 92637 97253 63299095
Ileus 54.76 16.33 86 92588 14639 63381709
Haematochezia 54.30 16.33 7 92667 53537 63342811
Dry skin 54.07 16.33 9 92665 56878 63339470
Therapy cessation 53.99 16.33 130 92544 30327 63366021
Visual impairment 53.81 16.33 28 92646 84418 63311930
Wrong product administered 53.75 16.33 55 92619 6086 63390262
Bronchitis 53.55 16.33 62 92612 124873 63271475
Sudden death 53.46 16.33 71 92603 10378 63385970
Night sweats 52.99 16.33 5 92669 48809 63347539
Multiple sclerosis relapse 52.54 16.33 5 92669 48473 63347875
Vomiting 52.53 16.33 543 92131 559074 62837274
Neck pain 52.14 16.33 18 92656 69300 63327048
Psychiatric evaluation 51.83 16.33 11 92663 14 63396334
Drug monitoring procedure incorrectly performed 51.73 16.33 17 92657 191 63396157
Persecutory delusion 50.95 16.33 38 92636 2752 63393596
Acute kidney injury 50.74 16.33 205 92469 263210 63133138
Liver injury 50.46 16.33 13 92661 60507 63335841
Gastrointestinal carcinoma 50.26 16.33 34 92640 2109 63394239
Dyspnoea exertional 50.19 16.33 13 92661 60289 63336059
Product use issue 50.19 16.33 160 92514 220360 63175988
Imprisonment 49.91 16.33 17 92657 215 63396133
Seizure 49.21 16.33 347 92327 132287 63264061
Chills 48.88 16.33 56 92618 113322 63283026
Hypokalaemia 48.40 16.33 48 92626 103756 63292592
Abdominal pain 47.79 16.33 243 92431 293213 63103135
Personality change due to a general medical condition 47.29 16.33 16 92658 198 63396150
Hyperkinesia 47.19 16.33 30 92644 1674 63394674
Bipolar disorder 46.88 16.33 58 92616 7902 63388446
Dizziness 46.79 16.33 402 92272 429523 62966825
Thrombosis 46.70 16.33 18 92656 64737 63331611
Pancreatic fibrosis 45.77 16.33 13 92661 85 63396263
Dysgeusia 45.27 16.33 7 92667 46703 63349645
Ill-defined disorder 45.26 16.33 32 92642 81723 63314625
High density lipoprotein decreased 45.18 16.33 32 92642 2138 63394210
Tobacco interaction 45.15 16.33 11 92663 35 63396313
Overweight 45.03 16.33 40 92634 3711 63392637
Medication error 44.95 16.33 173 92501 52111 63344237
Mean cell haemoglobin increased 44.83 16.33 36 92638 2907 63393441
Rhinorrhoea 44.44 16.33 20 92654 65557 63330791
Borderline personality disorder 43.48 16.33 22 92652 789 63395559
Red blood cell count increased 43.07 16.33 36 92638 3076 63393272
Urinary tract infection 43.02 16.33 582 92092 264102 63132246
Loss of consciousness 42.63 16.33 307 92367 117814 63278534
Bundle branch block right 42.37 16.33 44 92630 4954 63391394
Body temperature increased 42.30 16.33 135 92539 37057 63359291
Interstitial lung disease 41.77 16.33 19 92655 61889 63334459
Megacolon 41.64 16.33 29 92645 1886 63394462
Akinesia 41.53 16.33 27 92647 1566 63394782
Pain in jaw 41.07 16.33 7 92667 43489 63352859
Schizoaffective disorder bipolar type 41.01 16.33 13 92661 129 63396219
Insomnia 40.51 16.33 169 92505 215083 63181265
Skin ulcer 40.49 16.33 7 92667 43038 63353310
Gastrooesophageal reflux disease 40.40 16.33 48 92626 95591 63300757
Muscular weakness 40.35 16.33 73 92601 122280 63274068
Cardiac arrest 40.29 16.33 252 92422 92293 63304055
Negativism 40.21 16.33 17 92657 400 63395948
Feeling abnormal 40.17 16.33 99 92575 148293 63248055
Foreign body in gastrointestinal tract 39.89 16.33 10 92664 37 63396311
Dysarthria 39.77 16.33 145 92529 42566 63353782
Suicidal behaviour 39.60 16.33 32 92642 2607 63393741
Device expulsion 39.49 16.33 3 92671 34919 63361429
Burning sensation 39.44 16.33 15 92659 54392 63341956
Cervix neoplasm 39.36 16.33 14 92660 203 63396145
Fluid retention 39.21 16.33 19 92655 59667 63336681
Neutrophil count normal 38.72 16.33 7 92667 0 63396348
Sciatica 38.67 16.33 3 92671 34321 63362027
Myocardial fibrosis 38.65 16.33 20 92654 752 63395596
Metastatic neoplasm 38.56 16.33 39 92635 4256 63392092
Product dispensing error 38.06 16.33 60 92614 10245 63386103
Coma 37.81 16.33 190 92484 64174 63332174
Parkinson's disease 37.64 16.33 23 92651 1196 63395152
Serositis 37.58 16.33 19 92655 680 63395668
Gamma-glutamyltransferase increased 37.32 16.33 122 92552 33909 63362439
Psychotic behaviour 37.29 16.33 18 92656 582 63395766
Fibroma 37.13 16.33 20 92654 817 63395531
Depressed level of consciousness 36.99 16.33 184 92490 61894 63334454
Osteoporosis 36.55 16.33 19 92655 57319 63339029
Hip arthroplasty 36.48 16.33 12 92662 47634 63348714
Electroconvulsive therapy 36.37 16.33 10 92664 57 63396291
Stoma site pain 36.26 16.33 21 92653 989 63395359
Lethargy 36.25 16.33 170 92504 55837 63340511
Cataract 36.22 16.33 19 92655 57034 63339314
Social avoidant behaviour 36.14 16.33 32 92642 2956 63393392
Joint range of motion decreased 36.07 16.33 3 92671 32425 63363923
Hallucination, visual 35.96 16.33 84 92590 19214 63377134
Blood triglycerides increased 35.88 16.33 65 92609 12423 63383925
Palliative care 35.50 16.33 17 92657 540 63395808
Dry eye 35.46 16.33 8 92666 40753 63355595
Eye pain 35.37 16.33 4 92670 33850 63362498
Cardiac steatosis 35.35 16.33 9 92665 36 63396312
Central obesity 35.07 16.33 22 92652 1199 63395149
Blood bilirubin decreased 35.06 16.33 19 92655 786 63395562
Intellectual disability 34.85 16.33 21 92653 1065 63395283
Ankle fracture 34.68 16.33 79 92595 17776 63378572
Ovarian cancer 34.32 16.33 43 92631 5933 63390415
Galactorrhoea 34.19 16.33 36 92638 4119 63392229
Blood albumin decreased 34.02 16.33 70 92604 14696 63381652
Hepatitis C 33.62 16.33 40 92634 5234 63391114
Microcytosis 33.55 16.33 12 92662 177 63396171
Withdrawal catatonia 33.46 16.33 10 92664 80 63396268
Plasma cell myeloma 33.42 16.33 6 92668 35899 63360449
Affective disorder 33.37 16.33 43 92631 6103 63390245
Myocardial infarction 32.85 16.33 254 92420 99639 63296709
Intestinal strangulation 32.82 16.33 10 92664 86 63396262
Hepatotoxicity 32.77 16.33 7 92667 37034 63359314
Cystitis 32.50 16.33 20 92654 54971 63341377
Monocytosis 32.35 16.33 16 92658 546 63395802
Eye movement disorder 32.26 16.33 39 92635 5189 63391159
Parkinsonism hyperpyrexia syndrome 32.09 16.33 11 92663 142 63396206
Rash erythematous 32.04 16.33 11 92663 42499 63353849
Basophil count increased 31.99 16.33 19 92655 938 63395410
Granulocytosis 31.93 16.33 9 92665 57 63396291
Polydipsia 31.34 16.33 32 92642 3532 63392816
Self-injurious ideation 31.21 16.33 28 92646 2631 63393717
Swelling face 31.17 16.33 28 92646 63447 63332901
Skin exfoliation 31.05 16.33 12 92662 43090 63353258
Productive cough 30.90 16.33 28 92646 63180 63333168
Atrial fibrillation 30.64 16.33 79 92595 116557 63279791
Oral pain 30.58 16.33 3 92671 28391 63367957
Parotitis 30.52 16.33 22 92652 1511 63394837
Thrombocytopenia 30.39 16.33 346 92328 150811 63245537
Abnormal clotting factor 30.38 16.33 10 92664 113 63396235
Diverticulitis 30.22 16.33 10 92664 39547 63356801
Intestinal pseudo-obstruction 30.21 16.33 18 92656 894 63395454
International normalised ratio increased 30.16 16.33 15 92659 46410 63349938
Basal cell carcinoma 30.03 16.33 3 92671 27988 63368360
Dysphonia 30.02 16.33 16 92658 47598 63348750
Pseudophaeochromocytoma 30 16.33 9 92665 73 63396275
Swollen tongue 29.93 16.33 7 92667 34793 63361555
Impulsive behaviour 29.89 16.33 22 92652 1561 63394787
Mean platelet volume increased 29.62 16.33 15 92659 539 63395809
Joint stiffness 29.59 16.33 12 92662 41857 63354491
Product quality issue 29.33 16.33 8 92666 35857 63360491
Influenza B virus test positive 29.26 16.33 12 92662 261 63396087
Malignant catatonia 29.21 16.33 11 92663 189 63396159
Waxy flexibility 28.97 16.33 10 92664 132 63396216
Angioedema 28.97 16.33 17 92657 47948 63348400
Troponin abnormal 28.61 16.33 8 92666 49 63396299
Toxicologic test abnormal 28.60 16.33 16 92658 705 63395643
Mental status changes 28.47 16.33 124 92550 39475 63356873
Grandiosity 28.17 16.33 12 92662 288 63396060
Apathy 28.15 16.33 48 92626 8746 63387602
Nephrolithiasis 28.14 16.33 13 92661 41971 63354377
Hypocalcaemia 28.04 16.33 6 92668 31707 63364641
Hyperkalaemia 27.72 16.33 23 92651 54180 63342168
Chemotherapy 27.71 16.33 21 92653 1558 63394790
Echocardiogram abnormal 27.69 16.33 20 92654 1378 63394970
Injury 27.62 16.33 40 92634 73207 63323141
Pericarditis 27.50 16.33 99 92575 131480 63264868
Personality disorder 27.47 16.33 38 92636 5773 63390575
Thrombocytosis 27.44 16.33 38 92636 5780 63390568
Condition aggravated 27.26 16.33 418 92256 401799 62994549
Neuralgia 27.25 16.33 3 92671 25923 63370425
Tonic clonic movements 27.22 16.33 20 92654 1415 63394933
Blood phosphorus increased 27.22 16.33 28 92646 3117 63393231
Dysphemia 27.20 16.33 26 92648 2649 63393699
Arteriosclerosis coronary artery 27.20 16.33 46 92628 8327 63388021
Ataxia 27.08 16.33 65 92609 15130 63381218
Therapeutic product effect incomplete 26.87 16.33 93 92581 124963 63271385
Visceral congestion 26.72 16.33 12 92662 328 63396020
Stoma site reaction 26.62 16.33 11 92663 244 63396104
Rash maculo-papular 26.30 16.33 7 92667 31889 63364459
Psychomotor hyperactivity 26.30 16.33 52 92622 10611 63385737
Unresponsive to stimuli 25.94 16.33 108 92566 33708 63362640
Vision blurred 25.92 16.33 60 92614 91864 63304484
Eosinopenia 25.90 16.33 7 92667 37 63396311
Cardiac disorder 25.73 16.33 144 92530 50672 63345676
Pulmonary valve incompetence 25.62 16.33 19 92655 1364 63394984
C-reactive protein abnormal 25.56 16.33 18 92656 46078 63350270
Tinnitus 25.53 16.33 10 92664 35618 63360730
Body mass index increased 25.42 16.33 18 92656 1202 63395146
Asterixis 25.42 16.33 19 92655 1380 63394968
Liver function test abnormal 25.38 16.33 138 92536 48043 63348305
Osteonecrosis 25.37 16.33 3 92671 24527 63371821
Fungal infection 25.37 16.33 11 92663 36863 63359485
Oropharyngeal spasm 25.33 16.33 11 92663 277 63396071
Globulin abnormal 25.31 16.33 5 92669 3 63396345
Colitis ulcerative 25.08 16.33 4 92670 26087 63370261
Skin discolouration 24.91 16.33 12 92662 37816 63358532
Inflammation 24.59 16.33 52 92622 82221 63314127
Haematoma 24.58 16.33 10 92664 34810 63361538
Hepatic steatosis 24.56 16.33 95 92579 28674 63367674
Eye swelling 24.56 16.33 3 92671 23915 63372433
Ear pain 24.49 16.33 11 92663 36107 63360241
Blood bicarbonate increased 24.24 16.33 15 92659 798 63395550
Gynaecomastia 24.11 16.33 10 92664 224 63396124
Intestinal dilatation 24.00 16.33 20 92654 1702 63394646
Heart rate decreased 23.71 16.33 19 92655 45541 63350807
Confusional state 23.60 16.33 480 92194 235900 63160448
Stevens-Johnson syndrome 23.59 16.33 4 92670 24946 63371402
Prescribed underdose 23.58 16.33 7 92667 29682 63366666
Upper respiratory tract infection 23.58 16.33 53 92621 81994 63314354
Parotid gland enlargement 23.50 16.33 15 92659 843 63395505
Neglect of personal appearance 23.36 16.33 8 92666 103 63396245
Behaviour disorder 23.32 16.33 26 92648 3173 63393175
Left ventricular dysfunction 23.24 16.33 53 92621 11935 63384413
Hypochromasia 23.22 16.33 11 92663 341 63396007
Blood pressure systolic increased 23.16 16.33 21 92653 47376 63348972
Exposure during pregnancy 22.97 16.33 133 92541 155414 63240934
Gastric disorder 22.91 16.33 13 92661 37356 63358992
Asphyxia 22.84 16.33 36 92638 6145 63390203
Dry mouth 22.62 16.33 50 92624 77813 63318535
Rectal haemorrhage 22.47 16.33 23 92651 49007 63347341
Suspiciousness 22.44 16.33 11 92663 368 63395980
Haemoptysis 22.41 16.33 7 92667 28719 63367629
Live birth 22.36 16.33 5 92669 25625 63370723
Vertigo 22.28 16.33 33 92641 59854 63336494
Foreign body ingestion 22.12 16.33 4 92670 0 63396348
Catecholamines urine increased 22.12 16.33 4 92670 0 63396348
Activated partial thromboplastin time abnormal 22.12 16.33 8 92666 122 63396226
Gastrointestinal haemorrhage 22.08 16.33 54 92620 81122 63315226
Incoherent 21.98 16.33 30 92644 4500 63391848
Intervertebral disc protrusion 21.98 16.33 4 92670 23705 63372643
Neoplasm progression 21.87 16.33 13 92661 36415 63359933
Subileus 21.75 16.33 25 92649 3154 63393194
Neutrophil toxic granulation present 21.71 16.33 6 92668 35 63396313
Nervousness 21.70 16.33 9 92665 30970 63365378
Neutrophil percentage increased 21.59 16.33 24 92650 2919 63393429
Laryngeal cancer stage III 21.27 16.33 5 92669 13 63396335
Cervix cancer metastatic 21.15 16.33 6 92668 39 63396309
Frequent bowel movements 21.10 16.33 4 92670 23018 63373330
Cardiac failure congestive 21.05 16.33 67 92607 92366 63303982
Incontinence 20.99 16.33 50 92624 11582 63384766
Echolalia 20.93 16.33 9 92665 221 63396127
Palpitations 20.91 16.33 89 92585 112681 63283667
Poverty of speech 20.87 16.33 10 92664 318 63396030
Poor personal hygiene 20.76 16.33 10 92664 322 63396026
Nodule 20.72 16.33 3 92671 21023 63375325
Metamyelocyte count increased 20.68 16.33 9 92665 228 63396120
Drug level above therapeutic 20.62 16.33 30 92644 4775 63391573
Dementia with Lewy bodies 20.59 16.33 10 92664 328 63396020
Body mass index decreased 20.57 16.33 11 92663 443 63395905
Respiratory failure 20.39 16.33 233 92441 101625 63294723
Hypervolaemia 20.32 16.33 8 92666 28405 63367943
Glomerular filtration rate decreased 20.30 16.33 54 92620 13387 63382961
Stupor 20.28 16.33 28 92646 4247 63392101
Lip swelling 20.23 16.33 10 92664 31053 63365295
Physical assault 20.12 16.33 14 92660 909 63395439
Myelosuppression 19.93 16.33 5 92669 23698 63372650
Transferrin saturation decreased 19.92 16.33 13 92661 759 63395589
Cerebral haemorrhage 19.85 16.33 10 92664 30719 63365629
Accidental exposure to product 19.84 16.33 86 92588 27319 63369029
Wrong technique in product usage process 19.83 16.33 38 92636 62302 63334046
Brain neoplasm 19.82 16.33 28 92646 4338 63392010
Blunted affect 19.78 16.33 9 92665 254 63396094
Dehydration 19.75 16.33 160 92514 173194 63223154
Stoma site inflammation 19.72 16.33 11 92663 482 63395866
Left ventricular hypertrophy 19.70 16.33 31 92643 5284 63391064
Bradycardia 19.69 16.33 49 92625 73178 63323170
Haematuria 19.58 16.33 9 92665 29148 63367200
Hypophagia 19.58 16.33 94 92580 31165 63365183
Miosis 19.53 16.33 37 92637 7316 63389032
Electrocardiogram T wave amplitude decreased 19.50 16.33 10 92664 369 63395979
Bladder trabeculation 19.45 16.33 6 92668 54 63396294
Acne 19.42 16.33 5 92669 23288 63373060
Follicular lymphoma stage IV 19.36 16.33 4 92670 4 63396344
Procedural pain 19.24 16.33 4 92670 21565 63374783
Product administration error 19.15 16.33 74 92600 22323 63374025
Electrocardiogram PR shortened 19.15 16.33 9 92665 274 63396074
Hypomagnesaemia 19.10 16.33 9 92665 28728 63367620
Osteopenia 19.09 16.33 3 92671 19782 63376566
Nuchal rigidity 19.08 16.33 12 92662 657 63395691
Judgement impaired 19.03 16.33 13 92661 819 63395529
Drug-disease interaction 19.01 16.33 11 92663 517 63395831
Ventricular extrasystoles 18.72 16.33 48 92626 11639 63384709
Therapeutic product effect variable 18.71 16.33 15 92659 1208 63395140
Sexually inappropriate behaviour 18.66 16.33 7 92667 119 63396229
Musculoskeletal chest pain 18.62 16.33 4 92670 21079 63375269
Thyroxine free decreased 18.61 16.33 12 92662 686 63395662
Persistent depressive disorder 18.50 16.33 14 92660 1036 63395312
Thinking abnormal 18.40 16.33 45 92629 10598 63385750
Skin lesion 18.39 16.33 11 92663 30710 63365638
Anisocytosis 18.30 16.33 12 92662 706 63395642
Alcohol poisoning 18.29 16.33 18 92656 1901 63394447
Vascular encephalopathy 18.08 16.33 10 92664 431 63395917
Gait inability 17.99 16.33 31 92643 52928 63343420
Sleep disorder 17.96 16.33 60 92614 81506 63314842
Glaucoma 17.94 16.33 3 92671 18902 63377446
Speech disorder 17.90 16.33 111 92563 40518 63355830
Pulmonary embolism 17.87 16.33 254 92420 116430 63279918
QRS axis abnormal 17.87 16.33 14 92660 1091 63395257
Illness anxiety disorder 17.85 16.33 7 92667 135 63396213
Localised infection 17.83 16.33 11 92663 30199 63366149
Troponin I increased 17.72 16.33 19 92655 2219 63394129
Device related infection 17.72 16.33 6 92668 23386 63372962
Injection site mass 17.62 16.33 3 92671 18653 63377695
Drug eruption 17.57 16.33 10 92664 28684 63367664
Feeling hot 17.54 16.33 29 92645 50325 63346023
Disorientation 17.51 16.33 108 92566 39344 63357004
Lymphoma 17.44 16.33 48 92626 12139 63384209
Hyponatraemia 17.43 16.33 94 92580 111806 63284542
Drug monitoring procedure not performed 17.41 16.33 11 92663 607 63395741
Flatulence 17.41 16.33 15 92659 34687 63361661
Monocyte percentage increased 17.40 16.33 14 92660 1134 63395214
Drug dependence 17.33 16.33 7 92667 24476 63371872
Limb discomfort 17.29 16.33 11 92663 29705 63366643
Obesity 17.29 16.33 88 92586 29864 63366484
Gestational diabetes 17.26 16.33 38 92636 8358 63387990
Hyperthermia 17.22 16.33 40 92634 9116 63387232
Depressed mood 17.20 16.33 109 92565 40082 63356266
Joint injury 17.13 16.33 11 92663 29561 63366787
Lymphocyte percentage increased 17.13 16.33 10 92664 478 63395870
Sneezing 17.05 16.33 3 92671 18215 63378133
Gallbladder cholesterolosis 17.05 16.33 12 92662 794 63395554
Eczema eyelids 17.04 16.33 7 92667 153 63396195
Tooth disorder 16.97 16.33 10 92664 28147 63368201
Anxiety disorder 16.96 16.33 25 92649 4025 63392323
Blood cholesterol increased 16.95 16.33 75 92599 93957 63302391
Eye disorder 16.87 16.33 6 92668 22679 63373669
Breast cancer metastatic 16.87 16.33 47 92627 11971 63384377
Delusion of grandeur 16.80 16.33 8 92666 251 63396097
Anion gap increased 16.73 16.33 17 92657 1865 63394483
Intestinal ischaemia 16.73 16.33 35 92639 7433 63388915
Small cell lung cancer 16.72 16.33 16 92658 1633 63394715
Ischaemic stroke 16.71 16.33 3 92671 17954 63378394
Melaena 16.65 16.33 12 92662 30353 63365995
Appendicitis 16.64 16.33 37 92637 8192 63388156
Restlessness 16.63 16.33 86 92588 29367 63366981
Hallucination, olfactory 16.62 16.33 8 92666 257 63396091
Disturbance in attention 16.61 16.33 104 92570 38085 63358263
Myelocyte present 16.59 16.33 3 92671 0 63396348
Haemoglobinopathy 16.59 16.33 3 92671 0 63396348
Phobic avoidance 16.59 16.33 3 92671 0 63396348
Nothing by mouth order 16.59 16.33 3 92671 0 63396348
Electrocardiogram change 16.54 16.33 11 92663 663 63395685
Femur fracture 16.54 16.33 22 92652 41734 63354614
Gastritis 16.53 16.33 18 92656 37285 63359063
Non-high-density lipoprotein cholesterol increased 16.43 16.33 7 92667 168 63396180
Eating disorder 16.40 16.33 63 92611 18953 63377395
Grip strength decreased 16.39 16.33 6 92668 22281 63374067
Conjunctivitis 16.34 16.33 5 92669 20791 63375557

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hospitalisation 7022.94 14.94 3815 143558 53087 34756471
Neutropenia 5284.57 14.94 4724 142649 152054 34657504
Neutrophil count increased 4772.25 14.94 2014 145359 15132 34794426
White blood cell count increased 3987.53 14.94 2359 145014 38792 34770766
Neutrophilia 3434.48 14.94 1089 146284 3048 34806510
Granulocytopenia 3415.91 14.94 1216 146157 5351 34804207
Differential white blood cell count abnormal 2759.95 14.94 729 146644 730 34808828
Death 2184.04 14.94 5008 142365 393041 34416517
Antipsychotic drug level increased 2018.07 14.94 718 146655 3147 34806411
Myocarditis 1945.04 14.94 1011 146362 12671 34796887
Psychotic disorder 1803.53 14.94 1180 146193 23272 34786286
Mental impairment 1615.60 14.94 814 146559 9508 34800050
Neutrophil count decreased 1573.66 14.94 1470 145903 49634 34759924
Salivary hypersecretion 1550.39 14.94 748 146625 7896 34801662
White blood cell count decreased 1530.08 14.94 1945 145428 93500 34716058
Agranulocytosis 1489.80 14.94 1038 146335 22783 34786775
Treatment noncompliance 1065.93 14.94 910 146463 27190 34782368
Sedation 1015.91 14.94 784 146589 20222 34789336
Neuroleptic malignant syndrome 1006.88 14.94 732 146641 17202 34792356
Tachycardia 919.75 14.94 1434 145939 83338 34726220
Schizophrenia 853.31 14.94 503 146870 8163 34801395
Leukopenia 737.36 14.94 1103 146270 61753 34747805
Antipsychotic drug level decreased 662.63 14.94 223 147150 794 34808764
Platelet count increased 649.23 14.94 438 146935 9088 34800470
Hallucination, auditory 647.44 14.94 477 146896 11440 34798118
Mental disorder 639.53 14.94 523 146850 14686 34794872
Troponin increased 628.07 14.94 460 146913 10929 34798629
Eosinophil count increased 586.23 14.94 395 146978 8177 34801381
Antipsychotic drug level below therapeutic 544.71 14.94 249 147124 2298 34807260
Lower respiratory tract infection 515.34 14.94 651 146722 30986 34778572
Arthralgia 514.51 14.94 58 147315 169983 34639575
Rash 512.40 14.94 152 147221 222600 34586958
C-reactive protein increased 502.92 14.94 854 146519 53244 34756314
Acute kidney injury 493.91 14.94 342 147031 304646 34504912
Diarrhoea 485.89 14.94 559 146814 389353 34420205
Fatigue 467.58 14.94 526 146847 370127 34439431
Pruritus 465.28 14.94 35 147338 141946 34667612
Leukocytosis 456.62 14.94 535 146838 23530 34786028
Nausea 451.26 14.94 462 146911 339446 34470112
Catatonia 436.04 14.94 269 147104 4756 34804802
Delusion 426.19 14.94 383 146990 12252 34797306
Antipsychotic drug level above therapeutic 421.20 14.94 168 147205 1065 34808493
Eosinophil count decreased 420.81 14.94 175 147198 1253 34808305
Blood creatine phosphokinase increased 396.97 14.94 693 146680 44164 34765394
Pain 394.56 14.94 185 147188 204490 34605068
Monocyte count increased 389.23 14.94 244 147129 4443 34805115
Sinus tachycardia 375.25 14.94 413 146960 16947 34792611
Febrile neutropenia 368.73 14.94 66 147307 136783 34672775
Haemoglobin decreased 347.36 14.94 1209 146164 119563 34689995
Headache 344.65 14.94 210 147163 200425 34609133
Therapy interrupted 335.10 14.94 348 147025 13349 34796209
Malignant neoplasm progression 332.94 14.94 8 147365 88038 34721520
Faecaloma 330.39 14.94 232 147141 5145 34804413
Obsessive-compulsive disorder 323.25 14.94 232 147141 5332 34804226
Dyspnoea 310.18 14.94 709 146664 376073 34433485
Pain in extremity 302.29 14.94 80 147293 126433 34683125
Asthenia 302.09 14.94 354 147019 244897 34564661
Malaise 291.69 14.94 1548 145825 184277 34625281
Paranoia 267.55 14.94 291 147082 11777 34797781
Aggression 267.39 14.94 540 146833 38424 34771134
Mean cell haemoglobin decreased 265.18 14.94 134 147239 1572 34807986
Gastrointestinal hypomotility 261.66 14.94 115 147258 958 34808600
Red blood cell count decreased 260.61 14.94 452 146921 28638 34780920
Off label use 257.13 14.94 909 146464 418615 34390943
Erythema 254.38 14.94 36 147337 88744 34720814
Psychiatric decompensation 254.23 14.94 157 147216 2780 34806778
Back pain 252.07 14.94 99 147274 121690 34687868
Psychotic symptom 250.90 14.94 130 147243 1613 34807945
Decreased appetite 250.11 14.94 201 147172 166191 34643367
Disease progression 249.45 14.94 73 147300 108004 34701554
Lung neoplasm malignant 248.99 14.94 336 147037 17059 34792499
Atrial fibrillation 245.99 14.94 104 147269 122289 34687269
Hyperkalaemia 242.48 14.94 12 147361 69377 34740181
Oedema peripheral 240.48 14.94 102 147271 119710 34689848
Akathisia 238.95 14.94 228 147145 7881 34801677
Cardiomyopathy 238.05 14.94 323 147050 16485 34793073
Peripheral swelling 234.04 14.94 25 147348 76516 34733042
Lymphocyte count increased 232.28 14.94 156 147217 3209 34806349
Neuropathy peripheral 231.11 14.94 37 147336 83226 34726332
Pneumonia aspiration 227.18 14.94 528 146845 41375 34768183
Mean cell volume decreased 224.49 14.94 112 147261 1276 34808282
Urticaria 223.82 14.94 9 147364 62368 34747190
Eosinophilia 220.11 14.94 396 146977 25826 34783732
Imprisonment 217.05 14.94 82 147291 439 34809119
Abnormal behaviour 215.90 14.94 382 146991 24587 34784971
Drooling 210.29 14.94 147 147226 3235 34806323
Drug level increased 209.32 14.94 352 147021 21744 34787814
Extrapyramidal disorder 207.95 14.94 264 147109 12616 34796942
Joint swelling 207.22 14.94 11 147362 59879 34749679
Haematocrit decreased 203.99 14.94 432 146941 31784 34777774
Lymphocyte count decreased 201.95 14.94 351 147022 22271 34787287
Anosognosia 198.28 14.94 92 147281 881 34808677
Electrocardiogram QT prolonged 195.18 14.94 491 146882 40461 34769097
Drug hypersensitivity 194.01 14.94 50 147323 80479 34729079
Pre-existing disease 192.51 14.94 51 147322 52 34809506
Living in residential institution 190.65 14.94 72 147301 385 34809173
Neoplasm malignant 188.42 14.94 317 147056 19588 34789970
Schizoaffective disorder 188.22 14.94 98 147275 1229 34808329
Muscle rigidity 186.52 14.94 226 147147 10292 34799266
Agitation 184.53 14.94 597 146776 56802 34752756
Dyskinesia 182.41 14.94 334 147039 22079 34787479
Epistaxis 178.13 14.94 19 147354 58232 34751326
Obesity 177.10 14.94 244 147129 12634 34796924
Interstitial lung disease 174.56 14.94 32 147341 65250 34744308
Muscle spasms 172.38 14.94 51 147322 74950 34734608
Benign ethnic neutropenia 162.14 14.94 40 147333 21 34809537
Stomatitis 160.13 14.94 4 147369 42510 34767048
Paraesthesia 160.11 14.94 37 147336 64135 34745423
Anaemia 156.57 14.94 485 146888 232850 34576708
Tardive dyskinesia 155.98 14.94 155 147218 5635 34803923
Hypoaesthesia 154.15 14.94 35 147338 61409 34748149
Suicide attempt 153.06 14.94 436 146937 38680 34770878
Therapy cessation 151.02 14.94 263 147110 16710 34792848
Persecutory delusion 150.82 14.94 108 147265 2472 34807086
Enuresis 147.99 14.94 103 147270 2250 34807308
Neutrophil count abnormal 147.90 14.94 95 147278 1807 34807751
Delirium 147.23 14.94 464 146909 43527 34766031
Left ventricular dysfunction 145.79 14.94 195 147178 9812 34799746
Intentional product use issue 144.32 14.94 37 147336 59779 34749779
Orthostatic hypotension 144.17 14.94 330 147043 25589 34783969
General physical condition abnormal 143.80 14.94 123 147250 3676 34805882
Haematochezia 142.73 14.94 15 147358 46519 34763039
Circulatory collapse 142.39 14.94 290 147083 20748 34788810
Disinhibition 142.01 14.94 114 147259 3112 34806446
Therapeutic product effect variable 141.72 14.94 102 147271 2354 34807204
Mean cell haemoglobin concentration decreased 140.95 14.94 79 147294 1158 34808400
Ileus paralytic 140.64 14.94 149 147224 5848 34803710
Overdose 139.33 14.94 754 146619 90305 34719253
Platelet count decreased 138.87 14.94 922 146451 118795 34690763
Intestinal obstruction 138.66 14.94 301 147072 22521 34787037
International normalised ratio increased 138.34 14.94 18 147355 47309 34762249
Blood prolactin abnormal 135.83 14.94 71 147302 898 34808660
Hepatitis C 133.28 14.94 185 147188 9645 34799913
Pericarditis 132.91 14.94 202 147171 11443 34798115
Electrocardiogram abnormal 132.89 14.94 179 147194 9068 34800490
Renal failure 132.75 14.94 216 147157 130341 34679217
Cough 132.52 14.94 271 147102 149869 34659689
Injection site pain 132.34 14.94 8 147365 38997 34770561
Dystonia 132.18 14.94 194 147179 10651 34798907
COVID-19 129.54 14.94 658 146715 76892 34732666
Body temperature increased 129.10 14.94 249 147124 17119 34792439
Choking 127.30 14.94 130 147243 4885 34804673
Mean cell volume increased 126.93 14.94 106 147267 3063 34806495
Myalgia 125.72 14.94 102 147271 84008 34725550
Sinusitis 125.31 14.94 14 147359 41388 34768170
Megacolon 125.14 14.94 84 147289 1726 34807832
Hypokalaemia 122.54 14.94 46 147327 58168 34751390
Anaphylactic reaction 121.79 14.94 3 147370 32298 34777260
Hypersensitivity 120.72 14.94 53 147320 60982 34748576
Chills 120.23 14.94 99 147274 80944 34728614
Left ventricular hypertrophy 119.31 14.94 159 147214 7971 34801587
Thrombosis 118.34 14.94 33 147340 50425 34759133
Inappropriate schedule of product administration 117.18 14.94 58 147315 62238 34747320
Ascites 115.87 14.94 27 147346 46544 34763014
Troponin T increased 115.61 14.94 89 147284 2282 34807276
Rheumatoid arthritis 115.55 14.94 13 147360 38225 34771333
Cardiac failure congestive 114.77 14.94 109 147264 83161 34726397
Pancytopenia 114.02 14.94 140 147233 95017 34714541
Aspiration 113.80 14.94 193 147180 12001 34797557
Plasma cell myeloma 113.67 14.94 20 147353 42017 34767541
Bradycardia 113.28 14.94 91 147282 75327 34734231
Dizziness 113.25 14.94 505 146868 218016 34591542
Seizure 111.72 14.94 791 146582 104066 34705492
On and off phenomenon 107.29 14.94 87 147286 2410 34807148
Hypoglycaemia 107.18 14.94 48 147325 54592 34754966
Haemoglobin increased 106.45 14.94 99 147274 3310 34806248
Refusal of examination 104.54 14.94 24 147349 3 34809555
Thinking abnormal 104.16 14.94 129 147244 6008 34803550
Swelling 100.67 14.94 27 147346 42339 34767219
Disturbance in social behaviour 100.28 14.94 74 147299 1777 34807781
Lactic acidosis 99.77 14.94 14 147359 34758 34774800
Red cell distribution width increased 99.61 14.94 126 147247 5997 34803561
Gastrointestinal haemorrhage 97.97 14.94 138 147235 88339 34721219
Psoriasis 97.55 14.94 22 147351 38790 34770768
Myoclonus 97.30 14.94 201 147172 14524 34795034
Intestinal pseudo-obstruction 96.93 14.94 71 147302 1685 34807873
Psychiatric symptom 96.40 14.94 95 147278 3418 34806140
Dyspnoea exertional 94.83 14.94 32 147341 43247 34766311
Muscular weakness 94.08 14.94 101 147272 72796 34736762
Musculoskeletal pain 93.78 14.94 12 147361 31951 34777607
Wheezing 93.57 14.94 29 147344 41373 34768185
Euphoric mood 93.22 14.94 117 147256 5524 34804034
Heart rate increased 92.43 14.94 414 146959 45929 34763629
Somnolence 92.19 14.94 791 146582 110325 34699233
Delusional disorder, persecutory type 90.67 14.94 38 147335 278 34809280
Apathy 90.32 14.94 128 147245 6804 34802754
Renal impairment 89.95 14.94 163 147210 94350 34715208
Drug ineffective 89.93 14.94 1371 146002 455380 34354178
Hepatitis C virus test positive 89.24 14.94 39 147334 320 34809238
Haematuria 89.15 14.94 50 147323 50016 34759542
Dysgeusia 88.20 14.94 6 147367 26491 34783067
Weight decreased 87.95 14.94 413 146960 175888 34633670
Freezing phenomenon 86.82 14.94 63 147310 1473 34808085
Cardiac disorder 86.56 14.94 386 146987 42740 34766818
Dry skin 86.55 14.94 14 147359 31273 34778285
Psychiatric evaluation 84.99 14.94 19 147354 0 34809558
Echocardiogram abnormal 84.90 14.94 54 147319 1009 34808549
Vision blurred 84.62 14.94 44 147329 45919 34763639
Arthritis 84.56 14.94 15 147358 31331 34778227
Drug reaction with eosinophilia and systemic symptoms 84.41 14.94 18 147355 32994 34776564
Body mass index increased 84.34 14.94 54 147319 1021 34808537
Abdominal pain upper 83.71 14.94 107 147266 71383 34738175
Blood prolactin increased 83.50 14.94 65 147308 1695 34807863
Cytokine release syndrome 83.06 14.94 3 147370 22874 34786684
Oedema 82.43 14.94 45 147328 45696 34763862
Angioedema 79.54 14.94 29 147344 37345 34772213
Terminal state 78.82 14.94 90 147283 3844 34805714
Intentional self-injury 78.41 14.94 177 147196 13594 34795964
Hallucination 77.73 14.94 425 146948 51073 34758485
Coma scale abnormal 77.46 14.94 90 147283 3918 34805640
Sexual dysfunction 77.17 14.94 113 147260 6190 34803368
Rebound psychosis 76.64 14.94 29 147344 156 34809402
Generalised tonic-clonic seizure 76.07 14.94 229 147144 20945 34788613
Tobacco interaction 75.65 14.94 24 147349 67 34809491
Coronavirus infection 75.46 14.94 92 147281 4215 34805343
Rash pruritic 74.64 14.94 12 147361 26929 34782629
Troponin I increased 74.47 14.94 73 147300 2609 34806949
Mucosal inflammation 74.07 14.94 35 147338 38587 34770971
Congestive cardiomyopathy 72.91 14.94 121 147252 7389 34802169
Social avoidant behaviour 72.36 14.94 77 147296 3037 34806521
Skin exfoliation 72.12 14.94 14 147359 27418 34782140
Blood triglycerides increased 71.89 14.94 174 147199 13985 34795573
Prostate cancer 71.45 14.94 39 147334 39610 34769948
Haemorrhage 71.04 14.94 67 147306 51303 34758255
Herpes zoster 71.02 14.94 28 147345 34371 34775187
Pneumocystis jirovecii pneumonia 70.15 14.94 3 147370 19707 34789851
Increased appetite 69.87 14.94 118 147255 7311 34802247
Haematoma 69.62 14.94 12 147361 25593 34783965
Melaena 69.50 14.94 31 147342 35349 34774209
Metabolic disorder 69.45 14.94 88 147285 4195 34805363
Electrocardiogram T wave abnormal 69.25 14.94 56 147317 1545 34808013
Pneumonitis 69.25 14.94 28 147345 33850 34775708
Multiple organ dysfunction syndrome 68.50 14.94 137 147236 76429 34733129
Blood urea decreased 68.11 14.94 47 147326 1012 34808546
Cerebral haemorrhage 68.02 14.94 31 147342 34906 34774652
Colitis ischaemic 67.86 14.94 108 147265 6367 34803191
Rectal haemorrhage 67.71 14.94 43 147330 40206 34769352
Red blood cell count increased 67.50 14.94 55 147318 1534 34808024
Neutrophil count normal 67.10 14.94 15 147358 0 34809558
Mean cell haemoglobin concentration increased 66.44 14.94 33 147340 372 34809186
Parkinson's disease 66.28 14.94 52 147321 1372 34808186
Dehydration 66.23 14.94 302 147071 129667 34679891
Parkinsonism 65.84 14.94 121 147252 8017 34801541
Drug monitoring procedure incorrectly performed 65.21 14.94 28 147345 219 34809339
Insomnia 64.65 14.94 223 147150 103684 34705874
Stoma site discharge 64.60 14.94 48 147325 1165 34808393
Abdominal discomfort 64.57 14.94 95 147278 59740 34749818
Pulmonary valve incompetence 64.37 14.94 43 147330 876 34808682
Rash maculo-papular 64.15 14.94 20 147353 28431 34781127
Fluid retention 64.13 14.94 17 147356 26870 34782688
Sudden death 63.93 14.94 174 147199 15027 34794531
Abdominal pain 63.67 14.94 416 146957 163202 34646356
Ventricular tachycardia 63.03 14.94 17 147356 26562 34782996
Skin lesion 62.63 14.94 9 147364 21952 34787606
Bundle branch block right 62.39 14.94 113 147260 7403 34802155
Nephrolithiasis 62.11 14.94 25 147348 30308 34779250
Delusion of grandeur 62.00 14.94 46 147327 1114 34808444
Oculogyric crisis 61.36 14.94 52 147321 1534 34808024
Influenza like illness 61.32 14.94 255 147118 27379 34782179
Cerebral infarction 60.66 14.94 20 147353 27435 34782123
Condition aggravated 60.36 14.94 519 146854 191677 34617881
Hyponatraemia 60.31 14.94 165 147208 82526 34727032
Bronchitis 60.08 14.94 53 147320 41910 34767648
Osteoarthritis 59.95 14.94 8 147365 20634 34788924
Refusal of treatment by patient 59.85 14.94 89 147284 4943 34804615
Lung cancer metastatic 59.67 14.94 66 147307 2721 34806837
Acute myocardial infarction 59.23 14.94 84 147289 53635 34755923
Rash erythematous 59.18 14.94 16 147357 24961 34784597
Basophil count increased 59.05 14.94 34 147339 526 34809032
Cholestasis 58.90 14.94 20 147353 26928 34782630
Basal cell carcinoma 58.60 14.94 7 147366 19651 34789907
Gastrointestinal carcinoma 58.34 14.94 54 147319 1794 34807764
Tinnitus 57.95 14.94 8 147365 20110 34789448
Visual impairment 57.86 14.94 40 147333 35762 34773796
Constipation 57.08 14.94 852 146521 136130 34673428
Suspiciousness 56.74 14.94 28 147345 311 34809247
Hypocalcaemia 56.72 14.94 16 147357 24273 34785285
Haemoptysis 56.72 14.94 39 147334 34967 34774591
Withdrawal catatonia 56.11 14.94 20 147353 88 34809470
Hepatic function abnormal 55.53 14.94 63 147310 44300 34765258
Overweight 55.40 14.94 53 147320 1837 34807721
Type 2 diabetes mellitus 55.35 14.94 171 147202 15861 34793697
Myelosuppression 54.70 14.94 8 147365 19257 34790301
Cataract 54.57 14.94 21 147352 26165 34783393
Intestinal dilatation 54.34 14.94 44 147329 1216 34808342
Leukaemia 54.16 14.94 81 147292 4522 34805036
Nasopharyngitis 53.76 14.94 136 147237 69832 34739726
Blood creatinine increased 53.72 14.94 212 147161 94764 34714794
Investigation noncompliance 53.68 14.94 12 147361 0 34809558
Blister 53.49 14.94 15 147358 22843 34786715
Neck pain 53.38 14.94 20 147353 25329 34784229
Ejection fraction decreased 53.37 14.94 190 147183 18964 34790594
Heart rate decreased 53.28 14.94 34 147339 31711 34777847
Weight increased 53.12 14.94 613 146760 92420 34717138
Hyperbilirubinaemia 52.76 14.94 5 147368 16838 34792720
Diplopia 52.76 14.94 5 147368 16838 34792720
Full blood count decreased 52.56 14.94 7 147366 18081 34791477
Lip swelling 52.48 14.94 4 147369 16076 34793482
Impaired healing 52.45 14.94 3 147370 15331 34794227
Dry mouth 52.44 14.94 31 147342 30134 34779424
Coagulopathy 52.23 14.94 10 147363 19779 34789779
Viral infection 51.86 14.94 178 147195 17445 34792113
Pleurothotonus 51.80 14.94 42 147331 1163 34808395
Globulins decreased 51.78 14.94 23 147350 197 34809361
Neutrophil count 51.13 14.94 14 147359 18 34809540
Impaired self-care 51.12 14.94 43 147330 1255 34808303
Acute psychosis 50.87 14.94 50 147323 1793 34807765
Drug dose titration not performed 50.64 14.94 26 147347 316 34809242
Stoma site erythema 50.53 14.94 36 147337 817 34808741
Sedation complication 50.52 14.94 49 147324 1728 34807830
Septic shock 50.40 14.94 146 147227 71688 34737870
Gout 50.25 14.94 10 147363 19243 34790315
Polydipsia psychogenic 50.25 14.94 19 147354 102 34809456
Ventricular fibrillation 50.23 14.94 17 147356 22937 34786621
Gastrointestinal necrosis 50.22 14.94 67 147306 3362 34806196
Bone pain 49.48 14.94 13 147360 20673 34788885
Diverticulitis 48.95 14.94 12 147361 19992 34789566
Candida infection 48.83 14.94 8 147365 17707 34791851
Drug eruption 48.57 14.94 12 147361 19886 34789672
Volvulus 48.29 14.94 46 147327 1586 34807972
Coronary artery disease 48.02 14.94 81 147292 48224 34761334
QRS axis abnormal 47.79 14.94 41 147332 1230 34808328
Visual acuity reduced 47.52 14.94 6 147367 16143 34793415
Toxic epidermal necrolysis 47.42 14.94 16 147357 21630 34787928
Pericardial effusion 47.42 14.94 218 147155 24444 34785114
Suicidal ideation 47.29 14.94 312 147061 40076 34769482
Therapeutic product effect decreased 47.23 14.94 46 147327 34697 34774861
Dysuria 47.07 14.94 28 147345 27124 34782434
Prostatic specific antigen increased 46.94 14.94 4 147369 14676 34794882
Haemorrhage intracranial 46.74 14.94 6 147367 15940 34793618
Metabolic syndrome 46.72 14.94 46 147327 1653 34807905
Hypotension 46.62 14.94 656 146717 220993 34588565
Arthropathy 46.29 14.94 28 147345 26879 34782679
Deep vein thrombosis 46.23 14.94 132 147241 65116 34744442
Contusion 46.21 14.94 51 147322 36313 34773245
Staphylococcal infection 46.15 14.94 42 147331 32718 34776840
Myelodysplastic syndrome 46.08 14.94 12 147361 19196 34790362
Neuralgia 46.00 14.94 5 147368 15108 34794450
Drug intolerance 45.60 14.94 116 147257 59454 34750104
Hepatic failure 45.47 14.94 47 147326 34484 34775074
Rhinorrhoea 45.16 14.94 26 147347 25642 34783916
Burning sensation 45.08 14.94 11 147362 18383 34791175
Upper gastrointestinal haemorrhage 44.68 14.94 26 147347 25492 34784066
Disseminated intravascular coagulation 44.63 14.94 18 147355 21798 34787760
Swelling face 44.21 14.94 21 147352 23084 34786474
Wrong patient received product 43.78 14.94 55 147318 2599 34806959
Multiple sclerosis relapse 43.63 14.94 3 147370 13130 34796428
Hypoacusis 43.53 14.94 8 147365 16293 34793265
Hepatotoxicity 43.51 14.94 18 147355 21467 34788091
Pleural effusion 43.00 14.94 187 147186 81359 34728199
Monocyte count decreased 42.98 14.94 38 147335 1188 34808370
Device related infection 42.85 14.94 10 147363 17227 34792331
Obsessive thoughts 42.75 14.94 31 147342 724 34808834
Osteonecrosis 42.70 14.94 6 147367 14884 34794674
Chest discomfort 42.66 14.94 105 147268 54425 34755133
Bradykinesia 42.27 14.94 66 147307 3827 34805731
Mania 42.14 14.94 111 147262 9400 34800158
Dysphonia 42.13 14.94 23 147350 23360 34786198
Lymphoma 41.88 14.94 132 147241 12375 34797183
Respiratory failure 41.71 14.94 277 147096 108295 34701263
Hyperprolactinaemia 41.65 14.94 42 147331 1554 34808004
Loss of personal independence in daily activities 41.65 14.94 47 147326 33132 34776426
Eczema 41.49 14.94 13 147360 18423 34791135
Red cell distribution width decreased 41.40 14.94 19 147354 177 34809381
Stoma site inflammation 41.38 14.94 26 147347 475 34809083
Angina pectoris 40.95 14.94 43 147330 31320 34778238
Wrong technique in product usage process 40.94 14.94 55 147318 35931 34773627
Bacteraemia 40.78 14.94 16 147357 19701 34789857
Hypervolaemia 40.75 14.94 16 147357 19693 34789865
Product prescribing error 40.66 14.94 23 147350 22904 34786654
Flushing 40.61 14.94 46 147327 32374 34777184
Dementia 40.57 14.94 139 147234 13609 34795949
Appendicitis perforated 40.53 14.94 45 147328 1863 34807695
Ventricular hypokinesia 40.52 14.94 79 147294 5473 34804085
Total cholesterol/HDL ratio increased 40.34 14.94 18 147355 156 34809402
Jaundice 40.20 14.94 45 147328 31837 34777721
Inappropriate affect 40.11 14.94 29 147344 674 34808884
Mean platelet volume increased 40.04 14.94 26 147347 504 34809054
Product use in unapproved indication 39.71 14.94 311 147062 117188 34692370
Flatulence 39.44 14.94 20 147353 21178 34788380
Acute respiratory distress syndrome 39.39 14.94 31 147342 25938 34783620
Dilatation ventricular 39.36 14.94 52 147321 2584 34806974
Clostridium difficile colitis 39.35 14.94 9 147364 15721 34793837
Faecal vomiting 39.20 14.94 24 147349 418 34809140
Premature baby 38.88 14.94 17 147356 19616 34789942
Urinary incontinence 38.66 14.94 170 147203 18704 34790854
Contraindicated product administered 38.46 14.94 186 147187 21295 34788263
Fungal infection 38.14 14.94 10 147363 15925 34793633
Discomfort 38.14 14.94 16 147357 18922 34790636
Drowning 38.08 14.94 24 147349 441 34809117
Dysphemia 38.05 14.94 40 147333 1555 34808003
Affective disorder 38.05 14.94 67 147306 4293 34805265
Electrocardiogram T wave inversion 38.03 14.94 47 147326 2184 34807374
Sopor 37.84 14.94 125 147248 12011 34797547
Rebound effect 37.65 14.94 57 147316 3217 34806341
Obsessive-compulsive symptom 37.61 14.94 16 147357 122 34809436
Loss of libido 37.58 14.94 50 147323 2502 34807056
Chronic kidney disease 37.47 14.94 73 147300 41137 34768421
Stoma site reaction 37.44 14.94 19 147354 225 34809333
Ischaemic stroke 37.43 14.94 15 147358 18235 34791323
Waxy flexibility 37.35 14.94 15 147358 97 34809461
Monocytosis 37.34 14.94 24 147349 457 34809101
Dysarthria 37.33 14.94 263 147110 34519 34775039
Malignant catatonia 37.29 14.94 19 147354 227 34809331
Eye pain 37.28 14.94 6 147367 13456 34796102
Left atrial dilatation 37.20 14.94 44 147329 1952 34807606
Lymphocyte percentage increased 37.02 14.94 18 147355 193 34809365
Nasal congestion 36.94 14.94 26 147347 23031 34786527
SARS-CoV-2 test positive 36.88 14.94 79 147294 5854 34803704
Fibroma 36.81 14.94 22 147351 366 34809192
Ankle fracture 36.79 14.94 64 147309 4061 34805497
Toxic skin eruption 36.69 14.94 3 147370 11382 34798176
Product quality issue 36.61 14.94 13 147360 17022 34792536
Shock haemorrhagic 36.56 14.94 3 147370 11351 34798207
Feeling hot 36.46 14.94 18 147355 19354 34790204
Migraine 36.45 14.94 14 147359 17464 34792094
Clostridium difficile infection 36.43 14.94 17 147356 18881 34790677
Hypersplenism 36.38 14.94 23 147350 425 34809133
Productive cough 36.13 14.94 65 147308 37748 34771810
Drug-induced liver injury 36.02 14.94 41 147332 28791 34780767
Feeling abnormal 35.83 14.94 141 147232 63094 34746464
Waist circumference increased 35.65 14.94 30 147343 876 34808682
Electroencephalogram abnormal 35.65 14.94 48 147325 2430 34807128
Drug level changed 35.48 14.94 21 147352 343 34809215
Presyncope 35.44 14.94 18 147355 19041 34790517
Urinary tract infection 35.38 14.94 524 146849 83557 34726001
Neoplasm progression 35.10 14.94 28 147345 23272 34786286
Eosinophilic colitis 35.04 14.94 18 147355 219 34809339
Chromaturia 34.97 14.94 9 147364 14511 34795047
Frequent bowel movements 34.74 14.94 6 147367 12781 34796777
Blood test abnormal 34.67 14.94 85 147288 6886 34802672
Alopecia 34.57 14.94 31 147342 24324 34785234
Viral myocarditis 34.50 14.94 16 147357 153 34809405
Ocular hyperaemia 34.32 14.94 4 147369 11448 34798110
Foetal exposure during pregnancy 34.21 14.94 68 147305 38033 34771525
Proteinuria 34.07 14.94 18 147355 18624 34790934
Arteriosclerosis coronary artery 34.06 14.94 123 147250 12362 34797196
Cardiac failure 33.95 14.94 235 147138 91013 34718545
Incontinence 33.11 14.94 75 147298 5772 34803786
Mean cell haemoglobin increased 33.07 14.94 38 147335 1634 34807924
Dementia with Lewy bodies 33.04 14.94 26 147347 689 34808869
Obstructive airways disorder 33.00 14.94 12 147361 15482 34794076
Bone marrow failure 32.98 14.94 45 147328 29208 34780350
Blood bilirubin increased 32.98 14.94 70 147303 38226 34771332
Blindness 32.96 14.94 11 147362 14975 34794583
Skin discolouration 32.96 14.94 17 147356 17828 34791730
Hypercalcaemia 32.91 14.94 12 147361 15456 34794102
Spleen congestion 32.88 14.94 19 147354 296 34809262
Diabetes mellitus 32.88 14.94 322 147051 46551 34763007
Brain injury 32.82 14.94 77 147296 6065 34803493
Depression 32.80 14.94 257 147116 96841 34712717
Angina unstable 32.71 14.94 5 147368 11648 34797910
Personality change 32.60 14.94 69 147304 5070 34804488
Hyperglycaemia 32.49 14.94 74 147299 39406 34770152
Rash papular 32.33 14.94 3 147370 10275 34799283
Hot flush 32.21 14.94 18 147355 18048 34791510
Joint stiffness 32.09 14.94 4 147369 10869 34798689
Neurotoxicity 32.03 14.94 18 147355 17992 34791566
Treatment failure 31.96 14.94 96 147277 46601 34762957
Blood sodium increased 31.92 14.94 49 147324 2799 34806759
Hypoxia 31.76 14.94 122 147251 54973 34754585
Confusional state 31.74 14.94 814 146559 143346 34666212
Polydipsia 31.40 14.94 58 147315 3857 34805701
Blood pressure decreased 31.05 14.94 112 147261 51403 34758155
Throat irritation 30.98 14.94 4 147369 10581 34798977
Immature granulocyte count increased 30.92 14.94 14 147359 126 34809432
Encephalopathy 30.88 14.94 64 147309 35255 34774303
Blood pressure increased 30.78 14.94 231 147142 87871 34721687
Blood creatinine decreased 30.74 14.94 49 147324 2892 34806666
Skin ulcer 30.68 14.94 29 147344 22187 34787371
Anisocytosis 30.60 14.94 21 147352 448 34809110
Blood pressure systolic increased 30.49 14.94 31 147342 22921 34786637
Drug abuse 30.43 14.94 269 147104 98827 34710731
Hypoalbuminaemia 30.39 14.94 7 147366 12167 34797391
Delusional disorder, unspecified type 30.30 14.94 25 147348 710 34808848
Posture abnormal 30.14 14.94 42 147331 2197 34807361
Water intoxication 29.92 14.94 20 147353 408 34809150
Haemorrhoids 29.86 14.94 12 147361 14563 34794995
Amnesia 29.81 14.94 41 147332 26522 34783036
Electrocardiogram change 29.80 14.94 24 147349 658 34808900
Hepatic cytolysis 29.59 14.94 12 147361 14484 34795074
Suicidal behaviour 29.57 14.94 34 147339 1463 34808095
Epilepsy 29.51 14.94 173 147200 21322 34788236
Blood lactate dehydrogenase decreased 29.46 14.94 15 147358 179 34809379
Blood folate decreased 29.28 14.94 23 147350 608 34808950
Pulmonary hypertension 29.26 14.94 27 147346 20897 34788661
Anion gap increased 29.24 14.94 38 147335 1858 34807700
Pseudomonas infection 29.20 14.94 8 147365 12374 34797184
Lower limb fracture 29.20 14.94 58 147315 4073 34805485
Pulmonary fibrosis 29.13 14.94 21 147352 18375 34791183
Tricuspid valve incompetence 29.08 14.94 99 147274 9661 34799897
Gamma-glutamyltransferase increased 29.05 14.94 217 147156 29014 34780544
Psychotic behaviour 28.99 14.94 24 147349 685 34808873
Dyslipidaemia 28.81 14.94 83 147290 7405 34802153
Photosensitivity reaction 28.72 14.94 5 147368 10589 34798969
COVID-19 pneumonia 28.70 14.94 18 147355 16949 34792609
Enterococcal infection 28.52 14.94 3 147370 9303 34800255
Transaminases increased 28.52 14.94 43 147330 26780 34782778
Haemodialysis 28.47 14.94 5 147368 10521 34799037
Granulocytosis 28.46 14.94 16 147357 236 34809322
Lymphocytosis 28.41 14.94 44 147329 2533 34807025
Swollen tongue 28.36 14.94 13 147360 14592 34794966
Haemolytic anaemia 28.29 14.94 5 147368 10474 34799084
Lymphadenopathy 28.03 14.94 48 147325 28415 34781143
Akinesia 27.97 14.94 40 147333 2144 34807414
Polyneuropathy 27.80 14.94 14 147359 14882 34794676
Hypothermia 27.73 14.94 104 147269 10644 34798914
Purpura 27.66 14.94 5 147368 10306 34799252
Gastrooesophageal reflux disease 27.38 14.94 76 147297 37848 34771710
Substance use 27.35 14.94 23 147350 671 34808887
Colitis ulcerative 27.30 14.94 18 147355 16502 34793056
Electrocardiogram ST segment elevation 27.26 14.94 65 147308 5173 34804385
Foreign body ingestion 26.84 14.94 6 147367 0 34809558
Oxygen saturation decreased 26.81 14.94 126 147247 53692 34755866
Full blood count abnormal 26.77 14.94 152 147221 18516 34791042
Lymphocyte count abnormal 26.74 14.94 29 147344 1169 34808389
Palliative care 26.62 14.94 23 147350 697 34808861
Musculoskeletal stiffness 26.50 14.94 104 147269 46576 34762982
Autism spectrum disorder 26.44 14.94 40 147333 2256 34807302
Skin disorder 26.42 14.94 12 147361 13543 34796015
Alcohol abuse 26.38 14.94 60 147313 4630 34804928
Acne 26.38 14.94 7 147366 11059 34798499
Intervertebral disc protrusion 26.34 14.94 5 147368 9951 34799607
Acute myeloid leukaemia 26.24 14.94 23 147350 18247 34791311
Dyspepsia 26.24 14.94 74 147299 36658 34772900
Testicular germ cell cancer metastatic 26.10 14.94 10 147363 56 34809502
Mutism 26.05 14.94 25 147348 870 34808688
Blood disorder 26.04 14.94 49 147324 3305 34806253
Renal tubular necrosis 26.03 14.94 17 147356 15663 34793895
Erythema multiforme 25.97 14.94 3 147370 8646 34800912
Gastric ulcer 25.93 14.94 17 147356 15633 34793925
Staphylococcal sepsis 25.92 14.94 5 147368 9839 34799719
Tangentiality 25.85 14.94 12 147361 115 34809443
Learning disability 25.85 14.94 17 147356 337 34809221
Patient restraint 25.84 14.94 11 147362 84 34809474
Radiation inflammation 25.81 14.94 25 147348 880 34808678
Antisocial personality disorder 25.81 14.94 10 147363 58 34809500
Restlessness 25.79 14.94 190 147183 25292 34784266
Infection 25.79 14.94 532 146841 90383 34719175
Bundle branch block left 25.70 14.94 69 147304 5910 34803648
Blood cholesterol increased 25.45 14.94 161 147212 20382 34789176
Gastric haemorrhage 25.41 14.94 6 147367 10255 34799303
Reduced facial expression 25.39 14.94 27 147346 1064 34808494
Lacrimation increased 25.33 14.94 3 147370 8479 34801079
Hyperkinesia 25.06 14.94 34 147339 1734 34807824
Delusional perception 25.04 14.94 13 147360 162 34809396
Retrograde ejaculation 25.02 14.94 18 147355 415 34809143
Thought blocking 24.82 14.94 12 147361 127 34809431
Electrocardiogram QT interval abnormal 24.78 14.94 11 147362 94 34809464
Disorientation 24.76 14.94 231 147142 32957 34776601
High density lipoprotein decreased 24.75 14.94 48 147325 3312 34806246
End stage renal disease 24.42 14.94 4 147369 8857 34800701
Haematotoxicity 24.22 14.94 3 147370 8191 34801367
Testis cancer 24.19 14.94 30 147343 1399 34808159
Ideas of reference 24.16 14.94 9 147364 46 34809512
Bladder cancer 23.98 14.94 20 147353 16258 34793300
Seminoma 23.96 14.94 14 147359 223 34809335
Anuria 23.95 14.94 7 147366 10378 34799180
Encephalitis toxic 23.93 14.94 15 147358 273 34809285
Cardio-respiratory arrest 23.82 14.94 136 147237 55137 34754421
Skin cancer 23.64 14.94 7 147366 10290 34799268
Deafness 23.53 14.94 9 147364 11256 34798302
Subdural haematoma 23.44 14.94 31 147342 20390 34789168
Nervousness 23.29 14.94 12 147361 12594 34796964
Nephropathy toxic 23.24 14.94 12 147361 12576 34796982
Blunted affect 23.21 14.94 16 147357 344 34809214
Intestinal ischaemia 23.17 14.94 79 147294 7715 34801843
Large intestine polyp 23.14 14.94 3 147370 7911 34801647
Postmortem blood drug level increased 23.06 14.94 14 147359 240 34809318
Chronic hepatitis C 23.04 14.94 17 147356 408 34809150
Appendicectomy 23.04 14.94 26 147347 1096 34808462
Therapy non-responder 23 14.94 86 147287 39060 34770498
Bipolar disorder 22.97 14.94 49 147324 3620 34805938
Hepatic enzyme increased 22.87 14.94 86 147287 38994 34770564
Urine output decreased 22.77 14.94 7 147366 10042 34799516
Blood osmolarity decreased 22.66 14.94 19 147354 552 34809006
Oliguria 22.62 14.94 4 147369 8376 34801182
Hypertension 22.59 14.94 422 146951 136021 34673537
Vertigo 22.56 14.94 46 147327 25490 34784068
Intellectual disability 22.50 14.94 28 147345 1310 34808248
Pseudophaeochromocytoma 22.48 14.94 7 147366 18 34809540
Non-Hodgkin's lymphoma unspecified histology aggressive 22.37 14.94 5 147368 0 34809558
Empyema 22.35 14.94 45 147328 3191 34806367
Hypersensitivity myocarditis 22.30 14.94 8 147365 36 34809522
Pancreatitis acute 22.15 14.94 54 147319 28087 34781471
High-grade B-cell lymphoma 22.15 14.94 11 147362 124 34809434
Nightmare 22.05 14.94 17 147356 14374 34795184
Osteoporosis 22.04 14.94 13 147360 12655 34796903
Fall 22.03 14.94 1056 146317 201829 34607729
Pickwickian syndrome 21.93 14.94 9 147364 62 34809496
Bronchiectasis 21.90 14.94 7 147366 9794 34799764
Atrial flutter 21.89 14.94 20 147353 15554 34794004
Conduction disorder 21.84 14.94 35 147338 2075 34807483
Subacute endocarditis 21.81 14.94 9 147364 63 34809495
Stoma site extravasation 21.80 14.94 10 147363 93 34809465
C-reactive protein abnormal 21.75 14.94 5 147368 8705 34800853
Withdrawal syndrome 21.69 14.94 107 147266 12348 34797210
Amylase decreased 21.62 14.94 8 147365 40 34809518
Aplastic anaemia 21.60 14.94 7 147366 9709 34799849
Judgement impaired 21.52 14.94 19 147354 593 34808965
Blood osmolarity increased 21.51 14.94 16 147357 389 34809169
Substance abuse 21.46 14.94 76 147297 7565 34801993
Brain neoplasm 21.43 14.94 44 147329 3165 34806393
Face oedema 21.22 14.94 11 147362 11505 34798053
Rash macular 21.21 14.94 14 147359 12828 34796730
Osteomyelitis 21.20 14.94 22 147351 16114 34793444
Hiccups 21.15 14.94 8 147365 10074 34799484
Testicular cancer metastatic 21.11 14.94 9 147364 69 34809489
Tension 21.05 14.94 35 147338 2140 34807418
Cardiogenic shock 21.01 14.94 51 147322 26567 34782991
Quarantine 21.00 14.94 7 147366 24 34809534
Suspected COVID-19 20.95 14.94 26 147347 1213 34808345
Joint range of motion decreased 20.84 14.94 3 147370 7309 34802249
Incoherent 20.79 14.94 53 147320 4399 34805159
Cardiac failure chronic 20.75 14.94 4 147369 7875 34801683
Excessive masturbation 20.75 14.94 10 147363 105 34809453
Device malfunction 20.67 14.94 9 147364 10412 34799146
Subarachnoid haemorrhage 20.57 14.94 14 147359 12621 34796937
Hallucination, visual 20.55 14.94 137 147236 17654 34791904
Basophil count decreased 20.51 14.94 10 147363 108 34809450
Throat tightness 20.48 14.94 5 147368 8353 34801205
Hepatic encephalopathy 20.47 14.94 19 147354 14666 34794892
Drug titration error 20.42 14.94 17 147356 489 34809069
Intentional medical device removal by patient 20.39 14.94 14 147359 299 34809259
Liver disorder 20.37 14.94 71 147302 32926 34776632
Pulmonary haemorrhage 20.28 14.94 9 147364 10295 34799263
Oral candidiasis 20.28 14.94 13 147360 12097 34797461
Blood creatine phosphokinase decreased 20.22 14.94 17 147356 496 34809062
Illusion 20.20 14.94 21 147352 806 34808752
Thalassaemia 20.16 14.94 7 147366 28 34809530
Liver function test increased 20.12 14.94 19 147354 14546 34795012
Medication error 20.12 14.94 180 147193 25385 34784173
Myocardial fibrosis 20.05 14.94 25 147348 1172 34808386
Asthma 20.01 14.94 102 147271 42554 34767004
Aortic dilatation 19.94 14.94 27 147346 1374 34808184
Benign prostatic hyperplasia 19.92 14.94 19 147354 14476 34795082
Localised infection 19.88 14.94 27 147346 17560 34791998
Cholangitis 19.78 14.94 6 147367 8683 34800875
Microcytosis 19.70 14.94 11 147362 160 34809398
Electrolyte imbalance 19.68 14.94 19 147354 14393 34795165
Sepsis 19.68 14.94 543 146830 166018 34643540
Haemolysis 19.52 14.94 5 147368 8089 34801469
Musculoskeletal discomfort 19.43 14.94 5 147368 8063 34801495
Myasthenia gravis 19.43 14.94 3 147370 6937 34802621
Dermatitis bullous 19.36 14.94 3 147370 6919 34802639
Enterocolitis 19.28 14.94 5 147368 8021 34801537
Mean platelet volume decreased 19.25 14.94 16 147357 459 34809099
Sinus rhythm 19.21 14.94 15 147358 393 34809165
Heat stroke 19.20 14.94 22 147351 943 34808615
Status epilepticus 19.20 14.94 15 147358 12599 34796959
Alcohol problem 19.14 14.94 9 147364 89 34809469
Rehabilitation therapy 19.08 14.94 21 147352 861 34808697
Blood creatine decreased 19.06 14.94 9 147364 90 34809468
Fistula 19.05 14.94 3 147370 6837 34802721
Hyperosmolar state 19.04 14.94 15 147358 398 34809160
Oral pain 19.00 14.94 11 147362 10816 34798742
Musculoskeletal chest pain 18.99 14.94 9 147364 9909 34799649
Limb injury 18.96 14.94 13 147360 11676 34797882
Exposure during pregnancy 18.89 14.94 7 147366 8927 34800631
Peripheral sensory neuropathy 18.75 14.94 3 147370 6757 34802801
Drug dependence 18.65 14.94 47 147326 24170 34785388
Somatic delusion 18.63 14.94 9 147364 95 34809463
Somnolence neonatal 18.60 14.94 6 147367 18 34809540
Behaviour disorder 18.48 14.94 54 147319 4856 34804702
Myelocyte count increased 18.38 14.94 14 147359 353 34809205
Stab wound 18.38 14.94 12 147361 235 34809323
Drop attacks 18.34 14.94 17 147356 566 34808992
Crush syndrome 18.27 14.94 8 147365 66 34809492
ECG signs of myocardial ischaemia 18.25 14.94 11 147362 186 34809372
Neutrophil percentage decreased 18.25 14.94 14 147359 357 34809201
Unresponsive to stimuli 18.18 14.94 187 147186 27382 34782176
Lymphocyte morphology abnormal 18.16 14.94 16 147357 498 34809060
Acidosis 17.98 14.94 12 147361 10933 34798625
Priapism 17.92 14.94 54 147319 4940 34804618
Blood cannabinoids 17.89 14.94 4 147369 0 34809558
Cholinergic rebound syndrome 17.89 14.94 4 147369 0 34809558
Tooth disorder 17.79 14.94 12 147361 10870 34798688
Pollakiuria 17.75 14.94 35 147338 19639 34789919
Throat cancer 17.73 14.94 24 147349 1221 34808337
Eye disorder 17.71 14.94 9 147364 9519 34800039
Gender dysphoria 17.60 14.94 7 147366 44 34809514
Myositis 17.57 14.94 15 147358 12055 34797503
Alcohol detoxification 17.46 14.94 7 147366 45 34809513
Duodenal ulcer 17.42 14.94 11 147362 10321 34799237
Rib fracture 17.42 14.94 21 147352 14379 34795179
Embedded device 17.41 14.94 13 147360 318 34809240
Stupor 17.40 14.94 38 147335 2853 34806705
Anticholinergic syndrome 17.37 14.94 24 147349 1245 34808313
Generalised oedema 17.36 14.94 16 147357 12392 34797166
Eosinophilic pleural effusion 17.32 14.94 12 147361 260 34809298
Hypophagia 17.32 14.94 166 147207 23856 34785702
Coprolalia 17.28 14.94 6 147367 24 34809534
Compensatory sweating 17.28 14.94 6 147367 24 34809534
Stoma site discomfort 17.28 14.94 6 147367 24 34809534
Impaired work ability 17.26 14.94 4 147369 6926 34802632
Haematology test abnormal 17.21 14.94 7 147366 47 34809511
Pneumothorax 17.20 14.94 34 147339 19058 34790500
Mean cell volume abnormal 17.07 14.94 14 147359 394 34809164
Pneumonia bacterial 16.98 14.94 15 147358 11857 34797701
Catecholamines urine increased 16.92 14.94 5 147368 10 34809548
Basilar migraine 16.92 14.94 5 147368 10 34809548
Gait disturbance 16.79 14.94 255 147118 84885 34724673
Electrocardiogram ST-T change 16.76 14.94 16 147357 553 34809005
Colitis 16.74 14.94 92 147281 37658 34771900
Cardiomegaly 16.71 14.94 117 147256 15321 34794237
Mitral valve incompetence 16.62 14.94 114 147259 14829 34794729
Pulmonary pain 16.54 14.94 23 147350 1201 34808357
Soliloquy 16.52 14.94 14 147359 413 34809145
Stoma site irritation 16.49 14.94 10 147363 171 34809387
Electroconvulsive therapy 16.38 14.94 6 147367 29 34809529
Cardiac septal hypertrophy 16.30 14.94 12 147361 287 34809271
Eosinopenia 16.30 14.94 5 147368 12 34809546
Flank pain 16.25 14.94 4 147369 6647 34802911
Dialysis 16.23 14.94 14 147359 11194 34798364
Drug level fluctuating 16.16 14.94 15 147358 500 34809058
Epstein-Barr virus infection 16.09 14.94 6 147367 7622 34801936
Dermatitis 16.08 14.94 10 147363 9458 34800100
Rhinalgia 16.08 14.94 21 147352 1032 34808526
Product dispensing issue 16.06 14.94 7 147366 57 34809501
Flat affect 16.03 14.94 19 147354 845 34808713
Supraventricular tachycardia 15.96 14.94 14 147359 11103 34798455
Squamous cell carcinoma 15.82 14.94 15 147358 11460 34798098
Vascular dementia 15.77 14.94 15 147358 516 34809042
Syncope 15.70 14.94 281 147092 91170 34718388
Troponin abnormal 15.67 14.94 4 147369 3 34809555
Self-induced vomiting 15.67 14.94 4 147369 3 34809555
Atrioventricular block complete 15.61 14.94 10 147363 9309 34800249
Cardiac dysfunction 15.54 14.94 32 147341 2306 34807252
Hemiplegia 15.54 14.94 5 147368 6967 34802591
Norepinephrine increased 15.50 14.94 5 147368 15 34809543
Stoma site odour 15.46 14.94 6 147367 35 34809523
Electrocardiogram QT shortened 15.31 14.94 9 147364 145 34809413
Laparotomy 15.28 14.94 12 147361 317 34809241
Somatic dysfunction 15.26 14.94 5 147368 16 34809542
Poisoning deliberate 15.20 14.94 7 147366 7837 34801721
White blood cell disorder 15.20 14.94 26 147347 1627 34807931
Blood urea nitrogen/creatinine ratio decreased 15.18 14.94 6 147367 37 34809521
Aspartate aminotransferase increased 15.14 14.94 198 147175 67585 34741973
Blood pressure fluctuation 15.14 14.94 55 147318 25194 34784364
Infantile back arching 15.14 14.94 4 147369 4 34809554
Carditis 15.13 14.94 10 147363 200 34809358
Acute coronary syndrome 15.10 14.94 21 147352 13524 34796034
Viral pericarditis 15.04 14.94 6 147367 38 34809520
Dermatitis allergic 15.04 14.94 5 147368 6825 34802733
Gastric dilatation 15.04 14.94 17 147356 718 34808840

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Neutropenia 22953.09 15.93 11534 163472 276176 79293206
Neutrophil count increased 6919.67 15.93 2553 172453 26843 79542539
Neutrophilia 6344.81 15.93 1751 173255 6200 79563182
White blood cell count increased 5680.35 15.93 2921 172085 71712 79497670
Granulocytopenia 5344.49 15.93 1663 173343 9768 79559614
Differential white blood cell count abnormal 3721.35 15.93 873 174133 1204 79568178
Hospitalisation 2765.66 15.93 2005 173001 92231 79477151
Antipsychotic drug level increased 2621.89 15.93 828 174178 5129 79564253
Death 2515.65 15.93 4464 170542 562050 79007332
White blood cell count decreased 2495.09 15.93 2538 172468 185750 79383632
Salivary hypersecretion 2369.52 15.93 962 174044 13262 79556120
Myocarditis 2309.02 15.93 1070 173936 20663 79548719
Neutrophil count decreased 2222.64 15.93 1758 173248 92201 79477181
Agranulocytosis 2057.73 15.93 1263 173743 43767 79525615
Leukopenia 1661.60 15.93 1636 173370 114877 79454505
Psychotic disorder 1613.08 15.93 1050 173956 40352 79529030
Sedation 1506.76 15.93 1098 173908 50797 79518585
Neuroleptic malignant syndrome 1411.28 15.93 832 174174 26727 79542655
Mental impairment 1243.25 15.93 674 174332 18362 79551020
Platelet count increased 1052.50 15.93 640 174366 21766 79547616
Leukocytosis 949.63 15.93 777 174229 42678 79526704
Arthralgia 915.97 15.93 96 174910 571707 78997675
Tachycardia 912.43 15.93 1499 173507 176269 79393113
Pain 883.42 15.93 229 174777 703573 78865809
Anosognosia 840.48 15.93 315 174691 3449 79565933
Treatment noncompliance 831.17 15.93 780 174226 51488 79517894
Hallucination, auditory 830.66 15.93 535 174471 20158 79549224
Rash 783.51 15.93 159 174847 578199 78991183
Nausea 779.58 15.93 581 174425 956615 78612767
Haemoglobin decreased 758.31 15.93 1571 173435 220548 79348834
Blood prolactin abnormal 737.76 15.93 283 174723 3318 79566064
Headache 736.34 15.93 259 174747 653513 78915869
Eosinophil count decreased 724.91 15.93 275 174731 3121 79566261
Antipsychotic drug level decreased 699.49 15.93 208 174798 1016 79568366
Schizophrenia 696.89 15.93 430 174576 15010 79554372
Pruritus 672.55 15.93 51 174955 394597 79174785
Dyskinesia 671.55 15.93 647 174359 44126 79525256
Delusion 670.48 15.93 466 174540 19957 79549425
Disturbance in social behaviour 669.19 15.93 289 174717 4681 79564701
Catatonia 665.04 15.93 343 174663 8413 79560969
Dystonia 655.46 15.93 468 174538 20931 79548451
Antipsychotic drug level above therapeutic 652.80 15.93 224 174782 1856 79567526
Troponin increased 647.75 15.93 446 174560 18809 79550573
Fatigue 636.42 15.93 664 174342 929063 78640319
Sexual dysfunction 618.29 15.93 314 174692 7449 79561933
Eosinophil count increased 610.55 15.93 411 174595 16694 79552688
Diarrhoea 572.32 15.93 656 174350 879833 78689549
Metabolic disorder 558.10 15.93 310 174696 8860 79560522
C-reactive protein increased 543.84 15.93 998 174008 128029 79441353
Joint swelling 535.27 15.93 23 174983 288623 79280759
Sinus tachycardia 513.61 15.93 512 174494 36396 79532986
Antipsychotic drug level below therapeutic 503.06 15.93 162 174844 1076 79568306
Monocyte count increased 501.78 15.93 305 174701 10356 79559026
Dyspnoea 466.61 15.93 727 174279 856298 78713084
Blood creatine phosphokinase increased 463.25 15.93 645 174361 65445 79503937
Pain in extremity 457.50 15.93 118 174888 364420 79204962
Personality change 450.73 15.93 280 174726 9890 79559492
Extrapyramidal disorder 442.52 15.93 380 174626 22299 79547083
Eosinophilia 434.90 15.93 517 174489 44828 79524554
Drug hypersensitivity 434.86 15.93 68 174938 298848 79270534
Peripheral swelling 434.21 15.93 44 174962 269573 79299809
Drug level increased 428.86 15.93 481 174525 39170 79530212
Rheumatoid arthritis 421.83 15.93 7 174999 208463 79360919
Suicide attempt 421.67 15.93 697 174309 82235 79487147
Pre-existing disease 417.89 15.93 97 174909 123 79569259
Red blood cell count decreased 417.64 15.93 571 174435 56942 79512440
Mean cell haemoglobin decreased 413.57 15.93 223 174783 6001 79563381
Haematocrit decreased 396.70 15.93 576 174430 60736 79508646
Faecaloma 386.89 15.93 267 174739 11297 79558085
Swelling 386.56 15.93 22 174984 216689 79352693
Mental disorder 364.94 15.93 395 174611 30907 79538475
Back pain 363.73 15.93 108 174898 304072 79265310
Lymphocyte count decreased 362.38 15.93 482 174524 46807 79522575
Lymphocyte count increased 362.25 15.93 201 174805 5731 79563651
Alopecia 351.88 15.93 46 174960 231309 79338073
Sinusitis 351.30 15.93 19 174987 195482 79373900
Hypersensitivity 342.33 15.93 78 174928 262161 79307221
Aggression 340.27 15.93 486 174520 50472 79518910
Gastrointestinal hypomotility 337.19 15.93 136 174870 1837 79567545
Erythema 335.77 15.93 46 174960 223244 79346138
Mean cell haemoglobin concentration decreased 335.16 15.93 175 174831 4404 79564978
Urticaria 332.76 15.93 18 174988 185183 79384199
Paranoia 324.20 15.93 298 174708 19134 79550248
Platelet count decreased 323.46 15.93 1051 173955 193613 79375769
Electrocardiogram QT prolonged 319.23 15.93 649 174357 89737 79479645
Pneumonia aspiration 314.07 15.93 543 174463 66424 79502958
Asthenia 313.63 15.93 398 174608 511291 79058091
Agitation 305.88 15.93 676 174330 99039 79470343
Psychotic symptom 296.26 15.93 136 174870 2561 79566821
Mean cell volume decreased 294.92 15.93 165 174841 4782 79564600
Abdominal discomfort 292.51 15.93 93 174913 250634 79318748
Drug intolerance 289.12 15.93 109 174897 264010 79305372
Stomatitis 288.55 15.93 7 174999 146750 79422632
Acute kidney injury 286.29 15.93 436 174570 518968 79050414
Overdose 285.92 15.93 972 174034 183234 79386148
Psychiatric decompensation 285.90 15.93 150 174856 3813 79565569
Obsessive-compulsive disorder 285.18 15.93 172 174834 5755 79563627
Muscle rigidity 280.59 15.93 278 174728 19604 79549778
Arthropathy 279.66 15.93 31 174975 177080 79392302
Drug interaction 276.96 15.93 1706 173300 413477 79155905
Akathisia 276.79 15.93 231 174775 13028 79556354
Drooling 274.71 15.93 168 174838 5766 79563616
Malignant neoplasm progression 258.17 15.93 9 174997 135981 79433401
Nasopharyngitis 251.93 15.93 121 174885 253760 79315622
Febrile neutropenia 251.68 15.93 96 174910 230903 79338479
Living in residential institution 248.53 15.93 83 174923 627 79568755
Abnormal behaviour 248.50 15.93 351 174655 36070 79533312
Somnolence 246.15 15.93 1108 173898 237873 79331509
Decreased appetite 245.23 15.93 234 174772 342184 79227198
Hypoaesthesia 244.95 15.93 48 174958 179304 79390078
Injection site pain 241.66 15.93 10 174996 129828 79439554
Oedema peripheral 237.26 15.93 129 174877 252159 79317223
Enuresis 231.36 15.93 121 174885 3055 79566327
Therapy interrupted 228.72 15.93 312 174694 31029 79538353
Abdominal pain upper 226.17 15.93 104 174902 223715 79345667
Paraesthesia 224.97 15.93 55 174951 176268 79393114
Systemic lupus erythematosus 223.26 15.93 10 174996 121139 79448243
Red cell distribution width increased 222.30 15.93 217 174789 15025 79554357
Mean cell volume increased 215.37 15.93 147 174859 6106 79563276
Discomfort 214.32 15.93 16 174990 125601 79443781
Disease progression 213.87 15.93 69 174937 184293 79385089
Intentional product use issue 211.34 15.93 39 174967 152073 79417309
Therapeutic product effect decreased 211.24 15.93 50 174956 163813 79405569
Glossodynia 210.95 15.93 3 175003 103334 79466048
Cardiomyopathy 210.81 15.93 287 174719 28487 79540895
Cough 210.57 15.93 299 174707 366490 79202892
Blister 204.46 15.93 15 174991 119461 79449921
Benign ethnic neutropenia 199.44 15.93 43 174963 27 79569355
Arthritis 197.81 15.93 14 174992 114866 79454516
On and off phenomenon 192.96 15.93 108 174898 3132 79566250
Lung neoplasm malignant 192.79 15.93 270 174736 27522 79541860
Muscle spasms 191.31 15.93 72 174934 174658 79394724
Ileus paralytic 189.29 15.93 162 174844 9458 79559924
Intestinal obstruction 188.94 15.93 339 174667 42681 79526701
Pleurothotonus 183.69 15.93 96 174910 2420 79566962
Neuropathy peripheral 182.35 15.93 43 174963 141262 79428120
Aspiration 182.05 15.93 223 174783 19935 79549447
Tardive dyskinesia 181.96 15.93 165 174841 10406 79558976
Orthostatic hypotension 180.39 15.93 388 174618 55776 79513606
Wound 179.22 15.93 22 174984 116157 79453225
Generalised tonic-clonic seizure 178.94 15.93 335 174671 43575 79525807
Troponin T increased 176.70 15.93 105 174901 3417 79565965
Delirium 176.25 15.93 495 174511 84132 79485250
Epistaxis 174.79 15.93 20 174986 111495 79457887
Musculoskeletal pain 174.71 15.93 13 174993 102341 79467041
Blood glucose increased 173.27 15.93 601 174405 114374 79455008
Contusion 171.98 15.93 56 174950 148720 79420662
Impaired healing 169.22 15.93 5 175001 87650 79481732
Hyperkalaemia 166.24 15.93 26 174980 114372 79455010
Myoclonus 166.09 15.93 251 174755 27409 79541973
Schizoaffective disorder 165.41 15.93 85 174921 2067 79567315
Choking 164.84 15.93 166 174840 11935 79557447
Refusal of examination 164.52 15.93 46 174960 172 79569210
Off label use 156.05 15.93 1260 173746 905955 78663427
Osteoarthritis 152.17 15.93 10 174996 87299 79482083
Haemoglobin increased 151.69 15.93 118 174888 6014 79563368
Anaphylactic reaction 147.72 15.93 9 174997 83734 79485648
Hallucination 146.79 15.93 468 174538 85277 79484105
Atrial fibrillation 146.54 15.93 131 174875 197755 79371627
Psoriasis 145.71 15.93 14 174992 89573 79479809
Persecutory delusion 144.87 15.93 105 174901 4804 79564578
Megacolon 144.26 15.93 92 174914 3403 79565979
Psychiatric symptom 141.54 15.93 120 174886 6915 79562467
Hyperprolactinaemia 140.24 15.93 101 174905 4575 79564807
Myalgia 139.74 15.93 121 174885 185520 79383862
Wrong patient received product 139.08 15.93 100 174906 4518 79564864
Interstitial lung disease 138.09 15.93 38 174968 112562 79456820
Herpes zoster 135.60 15.93 21 174985 93062 79476320
Blood prolactin increased 135.08 15.93 93 174913 3918 79565464
Sudden death 134.77 15.93 204 174802 22307 79547075
Haematochezia 134.19 15.93 17 174989 87628 79481754
Seizure 133.21 15.93 788 174218 188046 79381336
Wheezing 132.92 15.93 45 174961 116619 79452763
Sopor 130.96 15.93 249 174757 32761 79536621
Maternal exposure during pregnancy 129.47 15.93 69 174937 136469 79432913
Hepatic enzyme increased 129.18 15.93 126 174880 182484 79386898
Intestinal pseudo-obstruction 128.85 15.93 77 174929 2532 79566850
Dizziness 128.76 15.93 656 174350 525785 79043597
Pericardial effusion 127.87 15.93 301 174705 45936 79523446
Fibromyalgia 126.70 15.93 3 175003 64337 79505045
Hypokalaemia 126.34 15.93 80 174926 143960 79425422
Parkinsonism 125.41 15.93 168 174838 16416 79552966
Oedema 124.77 15.93 53 174953 119527 79449855
Migraine 124.62 15.93 21 174985 87472 79481910
Inappropriate schedule of product administration 124.56 15.93 69 174937 133559 79435823
Electroencephalogram abnormal 120.36 15.93 98 174908 5336 79564046
General physical condition abnormal 118.01 15.93 105 174901 6458 79562924
Treatment failure 117.87 15.93 120 174886 170366 79399016
Bronchitis 116.74 15.93 71 174935 130573 79438809
Circulatory collapse 116.13 15.93 256 174750 37412 79531970
Psychiatric evaluation 116.09 15.93 24 174982 8 79569374
Left ventricular hypertrophy 112.90 15.93 131 174875 11060 79558322
International normalised ratio increased 112.87 15.93 24 174982 84697 79484685
Oculogyric crisis 112.73 15.93 74 174932 2878 79566504
Chills 111.67 15.93 112 174894 160122 79409260
Blood triglycerides increased 111.12 15.93 180 174826 20860 79548522
Rash pruritic 109.40 15.93 14 174992 71615 79497767
Freezing phenomenon 109.11 15.93 62 174944 1852 79567530
Muscular weakness 109.01 15.93 115 174891 160614 79408768
Constipation 108.49 15.93 1022 173984 282028 79287354
Gastrointestinal disorder 108.38 15.93 67 174939 122138 79447244
Left ventricular dysfunction 108.25 15.93 170 174836 19191 79550191
Neoplasm malignant 108.20 15.93 225 174781 31585 79537797
Folliculitis 107.47 15.93 3 175003 55377 79514005
Drug monitoring procedure incorrectly performed 102.67 15.93 39 174967 444 79568938
Thrombocytopenia 102.27 15.93 959 174047 264300 79305082
Therapy cessation 101.13 15.93 242 174764 37320 79532062
Rebound psychosis 100.94 15.93 36 174970 338 79569044
Weight decreased 100.77 15.93 419 174587 354779 79214603
Abdominal pain 100.60 15.93 476 174530 389093 79180289
Irritable bowel syndrome 100.50 15.93 10 174996 62231 79507151
Chest discomfort 100.25 15.93 93 174913 137951 79431431
Lung cancer metastatic 99.89 15.93 75 174931 3624 79565758
Delusion of grandeur 99.89 15.93 53 174953 1379 79568003
Musculoskeletal stiffness 97.99 15.93 145 174861 174863 79394519
Electrocardiogram abnormal 97.82 15.93 150 174856 16587 79552795
Dyspnoea exertional 96.75 15.93 35 174971 87038 79482344
Thrombosis 96.56 15.93 32 174974 84068 79485314
Dyspepsia 95.81 15.93 60 174946 108627 79460755
Stoma site discharge 95.81 15.93 60 174946 2149 79567233
Pulmonary valve incompetence 95.69 15.93 57 174949 1863 79567519
Monocyte count decreased 95.68 15.93 69 174937 3132 79566250
Nasal congestion 95.43 15.93 25 174981 76527 79492855
Gastrointestinal haemorrhage 95.42 15.93 110 174896 147609 79421773
Vomiting 93.65 15.93 972 174034 664856 78904526
Blood urea decreased 93.55 15.93 67 174939 3008 79566374
Red blood cell count increased 93.44 15.93 76 174930 4132 79565250
Hypothermia 93.23 15.93 174 174832 22572 79546810
Dysgeusia 92.80 15.93 9 174997 57168 79512214
Lower respiratory tract infection 92.21 15.93 541 174465 128679 79440703
Neutrophil count abnormal 91.91 15.93 70 174936 3456 79565926
Fluid retention 90.52 15.93 21 174985 69788 79499594
Renal failure 90.38 15.93 191 174815 200777 79368605
Refusal of treatment by patient 90.29 15.93 105 174901 8886 79560496
Neck pain 89.61 15.93 27 174979 75390 79493992
Terminal state 89.46 15.93 79 174927 4810 79564572
Congestive cardiomyopathy 88.56 15.93 119 174887 11661 79557721
Withdrawal catatonia 88.12 15.93 28 174978 177 79569205
Bradykinesia 87.66 15.93 98 174908 7945 79561437
Bone pain 87.33 15.93 10 174996 55732 79513650
Loss of personal independence in daily activities 87.19 15.93 59 174947 102521 79466861
Basophil count increased 86.52 15.93 49 174957 1454 79567928
Troponin I increased 85.58 15.93 76 174930 4662 79564720
Bundle branch block right 85.11 15.93 114 174892 11137 79558245
Drug ineffective 84.32 15.93 1772 173234 1079141 78490241
Metabolic syndrome 84.05 15.93 60 174946 2680 79566702
Dry skin 83.26 15.93 23 174983 67972 79501410
Urinary incontinence 82.90 15.93 237 174769 40672 79528710
Thinking abnormal 82.68 15.93 122 174884 13039 79556343
Bradycardia 82.21 15.93 106 174900 135451 79433931
Blood pressure increased 82.18 15.93 217 174789 211143 79358239
Rhinorrhoea 82.14 15.93 32 174974 76042 79493340
Swelling face 81.92 15.93 27 174979 71185 79498197
Tobacco interaction 81.89 15.93 22 174984 68 79569314
Pain in jaw 81.27 15.93 5 175001 46146 79523236
Visual impairment 81.01 15.93 51 174955 92080 79477302
Hypoglycaemia 80.41 15.93 63 174943 101531 79467851
Mutism 79.88 15.93 55 174951 2317 79567065
Stoma site erythema 79.53 15.93 49 174957 1704 79567678
Flushing 78.80 15.93 48 174958 88220 79481162
Epilepsy 78.27 15.93 232 174774 40628 79528754
Insomnia 78.00 15.93 276 174730 244894 79324488
Electrocardiogram T wave abnormal 77.75 15.93 65 174941 3673 79565709
Tinnitus 77.48 15.93 5 175001 44328 79525054
Body temperature increased 77.41 15.93 244 174762 44176 79525206
Exposure during pregnancy 77.19 15.93 65 174941 101067 79468315
Hepatitis C 77.03 15.93 112 174894 11813 79557569
Polyserositis 76.68 15.93 35 174971 650 79568732
Asthma 76.53 15.93 111 174895 134984 79434398
Ascites 76.43 15.93 35 174971 75527 79493855
Rectal haemorrhage 76.16 15.93 36 174970 76264 79493118
Apathy 75.41 15.93 116 174890 12861 79556521
Ileus 75.05 15.93 173 174833 26038 79543344
Mucosal inflammation 74.92 15.93 36 174970 75544 79493838
Colitis ischaemic 73.87 15.93 126 174880 15233 79554149
Hypertension 73.85 15.93 425 174581 330567 79238815
Multiple sclerosis relapse 73.77 15.93 8 174998 46525 79522857
Lactic acidosis 73.68 15.93 31 174975 70328 79499054
Impaired self-care 73.35 15.93 55 174951 2652 79566730
Haematoma 73.29 15.93 13 174993 52182 79517200
Mean cell haemoglobin concentration increased 73.28 15.93 37 174969 866 79568516
High density lipoprotein decreased 73.03 15.93 69 174937 4586 79564796
Stevens-Johnson syndrome 72.91 15.93 3 175003 39163 79530219
Suspiciousness 72.24 15.93 33 174973 614 79568768
Dysarthria 72.08 15.93 317 174689 67305 79502077
Burning sensation 71.48 15.93 20 174986 58612 79510770
Acute psychosis 71.46 15.93 65 174941 4115 79565267
Cytomegalovirus infection 71.13 15.93 6 175000 42638 79526744
Throat irritation 70.44 15.93 5 175001 40941 79528441
Vision blurred 70.41 15.93 77 174929 105821 79463561
Angioedema 69.78 15.93 40 174966 75995 79493387
Cerebral haemorrhage 69.70 15.93 20 174986 57653 79511729
Plasma cell myeloma 69.09 15.93 16 174990 53243 79516139
Malignant catatonia 69.09 15.93 29 174977 436 79568946
Rash maculo-papular 68.60 15.93 19 174987 56059 79513323
Rash erythematous 68.06 15.93 21 174985 57748 79511634
Waxy flexibility 68.00 15.93 25 174981 258 79569124
Mania 67.85 15.93 134 174872 18126 79551256
Posture abnormal 67.82 15.93 61 174945 3805 79565577
Diverticulitis 67.73 15.93 10 174996 45926 79523456
Hypomagnesaemia 67.38 15.93 11 174995 46900 79522482
Cataract 67.28 15.93 26 174980 62094 79507288
Imprisonment 66.93 15.93 30 174976 533 79568849
Eye pain 66.38 15.93 4 175002 37574 79531808
Hot flush 66.38 15.93 19 174987 54858 79514524
Cytokine release syndrome 66.21 15.93 3 175003 35995 79533387
Gastrointestinal necrosis 66.20 15.93 71 174935 5494 79563888
Feeling abnormal 66.10 15.93 158 174848 159041 79410341
Cardiac failure congestive 65.98 15.93 133 174873 142269 79427113
Basal cell carcinoma 65.96 15.93 4 175002 37371 79532011
Bursitis 65.88 15.93 3 175003 35841 79533541
Swollen tongue 65.78 15.93 8 174998 42562 79526820
Social avoidant behaviour 65.49 15.93 66 174940 4748 79564634
Skin exfoliation 64.96 15.93 20 174986 55080 79514302
Haematuria 64.92 15.93 35 174971 68801 79500581
Lymphoma 64.72 15.93 128 174878 17332 79552050
Therapeutic product effect variable 63.95 15.93 45 174961 1964 79567418
Intentional self-injury 63.93 15.93 186 174820 32233 79537149
C-reactive protein abnormal 63.81 15.93 14 174992 48353 79521029
Monocytosis 63.35 15.93 35 174971 989 79568393
Skin ulcer 63.22 15.93 20 174986 54130 79515252
Heart rate decreased 63.10 15.93 38 174968 70278 79499104
Dry mouth 63.06 15.93 60 174946 87959 79481423
Myocardial fibrosis 63.02 15.93 42 174964 1676 79567706
Mobility decreased 62.91 15.93 107 174899 122068 79447314
Hypocalcaemia 62.81 15.93 16 174990 49908 79519474
Coma scale abnormal 62.71 15.93 86 174920 8592 79560790
QRS axis abnormal 62.66 15.93 45 174961 2029 79567353
Affective disorder 62.48 15.93 84 174922 8235 79561147
Overweight 62.23 15.93 60 174946 4090 79565292
Muscle injury 62.18 15.93 15 174991 48546 79520836
Skin lesion 61.95 15.93 9 174997 41835 79527547
Hallucination, visual 61.89 15.93 185 174821 32544 79536838
Gastrooesophageal reflux disease 61.68 15.93 83 174923 104163 79465219
Nephrolithiasis 61.66 15.93 20 174986 53271 79516111
Osteoporosis 61.40 15.93 21 174985 54091 79515291
Renal impairment 61.31 15.93 162 174844 157621 79411761
Mean cell haemoglobin increased 60.61 15.93 60 174946 4225 79565157
Pseudophaeochromocytoma 60.51 15.93 18 174988 88 79569294
Joint range of motion decreased 60.48 15.93 3 175003 33279 79536103
Intestinal dilatation 60.45 15.93 49 174957 2651 79566731
Mean platelet volume increased 60.42 15.93 35 174971 1085 79568297
Obesity 60.34 15.93 192 174814 34933 79534449
Dehydration 60.11 15.93 310 174696 247877 79321505
Drug reaction with eosinophilia and systemic symptoms 60.10 15.93 33 174973 64211 79505171
Ill-defined disorder 59.96 15.93 35 174971 65840 79503542
Electrocardiogram T wave inversion 59.48 15.93 66 174940 5306 79564076
Dysphemia 59.21 15.93 54 174952 3430 79565952
Blood pressure systolic increased 59.00 15.93 37 174969 66949 79502433
Investigation noncompliance 58.82 15.93 12 174994 3 79569379
Depression 58.19 15.93 261 174745 216529 79352853
Hepatotoxicity 58.14 15.93 20 174986 51332 79518050
Haematocrit increased 58.01 15.93 57 174949 3977 79565405
Suicidal ideation 57.96 15.93 325 174681 76015 79493367
Hyperkinesia 57.90 15.93 48 174958 2681 79566701
Akinesia 57.59 15.93 52 174954 3260 79566122
Echocardiogram abnormal 57.57 15.93 44 174962 2184 79567198
Obsessive-compulsive symptom 57.22 15.93 20 174986 176 79569206
Arteriosclerosis coronary artery 57.09 15.93 123 174883 17693 79551689
Dry eye 56.92 15.93 7 174999 36924 79532458
Lymphocyte percentage increased 56.63 15.93 29 174977 700 79568682
Haemoptysis 56.54 15.93 26 174980 55973 79513409
Neutrophil count normal 56.36 15.93 11 174995 0 79569382
Polydipsia 56.31 15.93 71 174935 6534 79562848
Insurance issue 55.98 15.93 66 174940 5667 79563715
Disinhibition 55.75 15.93 46 174960 2552 79566830
Lip swelling 55.71 15.93 11 174995 40900 79528482
Joint stiffness 55.55 15.93 11 174995 40819 79528563
Polydipsia psychogenic 55.50 15.93 20 174986 194 79569188
Medication error 54.64 15.93 296 174710 68346 79501036
Feeling hot 53.99 15.93 32 174974 59702 79509680
Cystitis 53.99 15.93 24 174982 52708 79516674
Condition aggravated 53.12 15.93 777 174229 500347 79069035
Hyponatraemia 52.76 15.93 206 174800 177642 79391740
Haemorrhage 52.45 15.93 74 174932 91044 79478338
Neuralgia 52.26 15.93 6 175000 33378 79536004
Skin discolouration 51.91 15.93 13 174993 41021 79528361
Melaena 51.77 15.93 35 174971 60855 79508527
Gamma-glutamyltransferase increased 51.36 15.93 247 174759 54433 79514949
Toxic epidermal necrolysis 51.10 15.93 17 174989 44564 79524818
Pancytopenia 51.09 15.93 189 174817 165556 79403826
Dysphonia 50.66 15.93 31 174975 56841 79512541
Anion gap increased 50.61 15.93 51 174955 3669 79565713
Productive cough 50.58 15.93 72 174934 88259 79481123
Myelosuppression 50.52 15.93 13 174993 40283 79529099
Psychomotor hyperactivity 50.23 15.93 113 174893 16736 79552646
Hip arthroplasty 49.99 15.93 9 174997 35747 79533635
Body mass index increased 49.56 15.93 38 174968 1895 79567487
Hypervolaemia 49.43 15.93 16 174990 42674 79526708
Clostridium difficile infection 49.42 15.93 16 174990 42669 79526713
Globulins decreased 49.39 15.93 23 174983 448 79568934
Negativism 49.32 15.93 28 174978 835 79568547
Dementia 49.13 15.93 142 174864 24517 79544865
Restlessness 48.82 15.93 217 174789 46275 79523107
Candida infection 48.55 15.93 12 174994 38202 79531180
Pulmonary fibrosis 48.54 15.93 18 174988 44094 79525288
Oral herpes 48.26 15.93 3 175003 27451 79541931
Diabetes mellitus 48.24 15.93 316 174690 78074 79491308
Ejection fraction decreased 47.98 15.93 176 174830 34401 79534981
Malaise 47.79 15.93 1410 173596 488459 79080923
Tricuspid valve incompetence 47.77 15.93 122 174884 19590 79549792
Acne 47.71 15.93 3 175003 27187 79542195
Knee arthroplasty 47.00 15.93 18 174988 43230 79526152
Cholestasis 46.98 15.93 28 174978 52081 79517301
Subileus 46.97 15.93 60 174946 5594 79563788
Stoma site inflammation 46.41 15.93 25 174981 671 79568711
Delusional disorder, unspecified type 46.39 15.93 26 174980 756 79568626
Haemorrhoids 46.19 15.93 5 175001 29123 79540259
Foreign body ingestion 46.12 15.93 9 174997 0 79569382
Fungal infection 46 15.93 17 174989 41731 79527651
Posterior reversible encephalopathy syndrome 45.82 15.93 3 175003 26278 79543104
Fibroma 45.73 15.93 27 174979 868 79568514
Diplopia 45.56 15.93 9 174997 33457 79535925
Nervousness 45.46 15.93 9 174997 33406 79535976
Pneumonitis 45.36 15.93 40 174966 60820 79508562
Osteonecrosis 45.31 15.93 7 174999 31088 79538294
COVID-19 45.13 15.93 537 174469 157137 79412245
Frequent bowel movements 44.56 15.93 6 175000 29533 79539849
Wrong technique in product usage process 44.54 15.93 58 174948 73817 79495565
Product use issue 44.33 15.93 274 174732 209548 79359834
Neutrophil count 44.33 15.93 17 174989 199 79569183
Angina pectoris 43.62 15.93 30 174976 51702 79517680
Joint injury 43.57 15.93 8 174998 31327 79538055
Injury 43.55 15.93 64 174942 77432 79491950
Drug eruption 43.43 15.93 21 174985 43914 79525468
Palpitations 43.33 15.93 138 174868 126472 79442910
Device related infection 43.12 15.93 11 174995 34283 79535099
Ventricular tachycardia 43.07 15.93 19 174987 41916 79527466
Tooth disorder 42.91 15.93 4 175002 26229 79543153
Drug dose titration not performed 42.87 15.93 25 174981 785 79568597
Haemorrhage intracranial 42.83 15.93 4 175002 26189 79543193
Gastrointestinal carcinoma 42.65 15.93 44 174962 3255 79566127
Coronavirus infection 42.14 15.93 66 174940 7431 79561951
Delusional disorder, persecutory type 41.77 15.93 21 174985 487 79568895
Upper respiratory tract infection 41.50 15.93 86 174920 91082 79478300
Throat tightness 41.31 15.93 6 175000 27901 79541481
Blood bilirubin decreased 41.17 15.93 27 174979 1048 79568334
Inappropriate affect 41.16 15.93 31 174975 1505 79567877
Volvulus 41.13 15.93 40 174966 2756 79566626
Euphoric mood 40.66 15.93 66 174940 7660 79561722
Behaviour disorder 40.35 15.93 59 174947 6254 79563128
Radiation inflammation 40.31 15.93 25 174981 880 79568502
Postmortem blood drug level increased 40.27 15.93 24 174982 785 79568597
Blood pressure fluctuation 40.19 15.93 53 174953 67092 79502290
Hepatic failure 40.14 15.93 45 174961 61167 79508215
Visual acuity reduced 39.96 15.93 8 174998 29461 79539921
Pneumocystis jirovecii pneumonia 39.79 15.93 11 174995 32497 79536885
Rebound effect 39.77 15.93 63 174943 7163 79562219
Ocular hyperaemia 39.65 15.93 7 174999 28199 79541183
Device expulsion 39.62 15.93 5 175001 25856 79543526
Hepatitis C virus test positive 39.55 15.93 19 174987 398 79568984
Liver function test increased 39.33 15.93 19 174987 39754 79529628
Blood folate decreased 39.02 15.93 28 174978 1261 79568121
Pancreatic fibrosis 38.83 15.93 13 174993 99 79569283
Ear pain 38.62 15.93 12 174994 32857 79536525
Colitis ulcerative 38.53 15.93 14 174992 34728 79534654
Lymphadenopathy 38.49 15.93 36 174970 53211 79516171
Neoplasm progression 38.48 15.93 34 174972 51648 79517734
Blindness 37.88 15.93 8 174998 28375 79541007
Cerebral infarction 37.84 15.93 27 174979 45649 79523733
Liver injury 37.81 15.93 41 174965 56573 79512809
Catecholamines urine increased 37.70 15.93 9 174997 14 79569368
Bronchopulmonary aspergillosis 37.56 15.93 3 175003 22291 79547091
Blood creatinine decreased 37.38 15.93 64 174942 7761 79561621
Anisocytosis 37.15 15.93 25 174981 1014 79568368
Hyperbilirubinaemia 36.93 15.93 5 175001 24513 79544869
Intentional overdose 36.80 15.93 375 174631 105585 79463797
Night sweats 36.75 15.93 36 174970 52059 79517323
Stoma site irritation 36.71 15.93 16 174990 265 79569117
Stupor 36.57 15.93 59 174947 6813 79562569
Judgement impaired 36.54 15.93 27 174979 1273 79568109
Procedural pain 36.51 15.93 4 175002 23080 79546302
Blunted affect 36.39 15.93 19 174987 478 79568904
Intestinal ischaemia 36.26 15.93 86 174920 13184 79556198
Intellectual disability 36.17 15.93 27 174979 1293 79568089
Coagulopathy 35.91 15.93 17 174989 35989 79533393
Blood osmolarity increased 35.79 15.93 21 174985 667 79568715
Schizoaffective disorder bipolar type 35.65 15.93 15 174991 227 79569155
Ventricular hypokinesia 35.58 15.93 69 174937 9210 79560172
Product quality issue 35.46 15.93 15 174991 33925 79535457
Cervix neoplasm 35.40 15.93 14 174992 179 79569203
Faecal vomiting 35.37 15.93 25 174981 1099 79568283
Immature granulocyte count increased 35.24 15.93 20 174986 596 79568786
Obsessive thoughts 35.21 15.93 25 174981 1107 79568275
Lymphocyte count abnormal 35.19 15.93 28 174978 1475 79567907
Vertigo 35.10 15.93 61 174945 69021 79500361
Spleen congestion 35.09 15.93 18 174988 436 79568946
Dysuria 35.03 15.93 36 174970 50915 79518467
Echolalia 35.00 15.93 17 174989 365 79569017
Lung disorder 34.99 15.93 78 174928 80479 79488903
Liver disorder 34.95 15.93 66 174940 72351 79497031
Oral pain 34.95 15.93 13 174993 31785 79537597
Abdominal pain lower 34.92 15.93 13 174993 31769 79537613
Priapism 34.61 15.93 46 174960 4459 79564923
Impulsive behaviour 34.50 15.93 37 174969 2863 79566519
Seminoma 34.19 15.93 14 174992 197 79569185
Neutrophil percentage decreased 34.18 15.93 22 174984 827 79568555
Clostridium difficile colitis 34.16 15.93 14 174992 32269 79537113
Localised infection 34.14 15.93 20 174986 37555 79531827
Stoma site reaction 33.94 15.93 17 174989 391 79568991
Gastric disorder 33.91 15.93 20 174986 37413 79531969
Blood sodium increased 33.84 15.93 47 174959 4751 79564631
Ideas of reference 33.54 15.93 13 174993 157 79569225
Toxicity to various agents 33.45 15.93 1184 173822 420356 79149026
Deep vein thrombosis 33.38 15.93 144 174862 120775 79448607
Ulcer 33.37 15.93 12 174994 29960 79539422
Musculoskeletal disorder 33.21 15.93 4 175002 21444 79547938
Flatulence 33.16 15.93 27 174979 42697 79526685
Coronary artery disease 33.09 15.93 58 174948 65416 79503966
Jaundice 33.08 15.93 41 174965 53308 79516074
Musculoskeletal chest pain 33.01 15.93 7 174999 24757 79544625
Transfusion 32.98 15.93 4 175002 21326 79548056
Shock haemorrhagic 32.97 15.93 3 175003 20057 79549325
Cardiac disorder 32.83 15.93 252 174754 65505 79503877
Gait inability 32.77 15.93 49 174957 58868 79510514
Obstructive airways disorder 32.71 15.93 14 174992 31445 79537937
Prescribed underdose 32.55 15.93 12 174994 29502 79539880
Eye disorder 32.50 15.93 6 175000 23406 79545976
Ischaemic stroke 32.50 15.93 16 174990 33115 79536267
Glaucoma 32.36 15.93 3 175003 19758 79549624
Personality change due to a general medical condition 32.34 15.93 14 174992 228 79569154
Blood disorder 32.31 15.93 62 174944 8211 79561171
Monocyte percentage increased 32.19 15.93 31 174975 2110 79567272
Parkinsonism hyperpyrexia syndrome 32.01 15.93 14 174992 234 79569148
Oxygen saturation decreased 31.89 15.93 160 174846 128887 79440495
Visceral congestion 31.80 15.93 22 174984 934 79568448
Protein total decreased 31.72 15.93 65 174941 9027 79560355
Incontinence 31.60 15.93 85 174921 14079 79555303
Electroconvulsive therapy 31.55 15.93 11 174995 96 79569286
Central obesity 31.32 15.93 28 174978 1733 79567649
Blood lactate dehydrogenase decreased 31.19 15.93 15 174991 315 79569067
Drug level changed 31.10 15.93 18 174988 557 79568825
Bone disorder 31.04 15.93 3 175003 19110 79550272
Gout 31.00 15.93 8 174998 24741 79544641
Drug level fluctuating 30.90 15.93 20 174986 759 79568623
Eosinophilic colitis 30.88 15.93 17 174989 477 79568905
Hypersplenism 30.73 15.93 18 174988 570 79568812
Total cholesterol/HDL ratio increased 30.72 15.93 14 174992 259 79569123
Lacrimation increased 30.69 15.93 6 175000 22471 79546911
Injection site mass 30.68 15.93 4 175002 20180 79549202
Mitral valve incompetence 30.50 15.93 134 174872 28431 79540951
Incoherent 30.47 15.93 58 174948 7634 79561748
Chronic obstructive pulmonary disease 30.47 15.93 304 174702 85115 79484267
Product prescribing error 30.43 15.93 32 174974 44781 79524601
Confusional state 30.33 15.93 913 174093 317084 79252298
Unresponsive to stimuli 30.23 15.93 218 174788 55570 79513812
Neutrophil percentage increased 30.23 15.93 44 174962 4645 79564737
Hypercalcaemia 30.19 15.93 24 174982 38406 79530976
Musculoskeletal discomfort 29.99 15.93 4 175002 19831 79549551
SARS-CoV-2 test positive 29.95 15.93 74 174932 11642 79557740
Disseminated intravascular coagulation 29.94 15.93 21 174985 35821 79533561
Basophil count decreased 29.86 15.93 14 174992 277 79569105
Lethargy 29.82 15.93 291 174715 81001 79488381
Depressed level of consciousness 29.80 15.93 334 174672 96318 79473064
Encephalitis toxic 29.77 15.93 14 174992 279 79569103
Cardiac steatosis 29.77 15.93 9 174997 47 79569335
Pulmonary hypertension 29.76 15.93 37 174969 48043 79521339
Impaired work ability 29.68 15.93 4 175002 19677 79549705
Nodule 29.64 15.93 7 174999 22987 79546395
Skin disorder 29.54 15.93 19 174987 33924 79535458
Grip strength decreased 29.52 15.93 6 175000 21863 79547519
Withdrawal syndrome 29.46 15.93 127 174879 26727 79542655
Presyncope 29.39 15.93 28 174978 41026 79528356
Limb injury 29.36 15.93 14 174992 29514 79539868
Metamyelocyte count increased 29.32 15.93 18 174988 622 79568760
Eosinopenia 29.30 15.93 9 174997 50 79569332
Femur fracture 29.29 15.93 25 174981 38627 79530755
Drug-disease interaction 29.26 15.93 22 174984 1065 79568317
Electrocardiogram ST segment elevation 29.26 15.93 60 174946 8337 79561045
Thought blocking 29.21 15.93 13 174993 227 79569155
Osteomyelitis 29.15 15.93 18 174988 32847 79536535
Serositis 29.14 15.93 20 174986 838 79568544
Electrocardiogram T wave amplitude decreased 29.12 15.93 19 174987 731 79568651
Disorientation 28.83 15.93 236 174770 62540 79506842
Cellulitis 28.82 15.93 132 174874 108928 79460454
Myelocyte count increased 28.69 15.93 19 174987 750 79568632
Left atrial dilatation 28.66 15.93 35 174971 3118 79566264
B-cell lymphoma 28.60 15.93 50 174956 6165 79563217
High-grade B-cell lymphoma 28.51 15.93 11 174995 131 79569251
Bronchiectasis 28.49 15.93 7 174999 22379 79547003
Testicular germ cell cancer metastatic 28.44 15.93 9 174997 56 79569326
Dilatation ventricular 28.35 15.93 40 174966 4104 79565278
Amnesia 28.26 15.93 60 174946 62997 79506385
Hepatic steatosis 28.20 15.93 160 174846 37578 79531804
Gastric ulcer 28.14 15.93 20 174986 33885 79535497
Blood alkaline phosphatase increased 27.99 15.93 237 174769 63427 79505955
Hypophagia 27.98 15.93 183 174823 45184 79524198
Drug titration error 27.96 15.93 22 174984 1140 79568242
Patient restraint 27.94 15.93 10 174996 95 79569287
Drug-induced liver injury 27.92 15.93 65 174941 66052 79503330
Suicidal behaviour 27.84 15.93 35 174971 3212 79566170
Eosinophilic pleural effusion 27.83 15.93 14 174992 325 79569057
Live birth 27.82 15.93 4 175002 18740 79550642
Limb discomfort 27.76 15.93 19 174987 32831 79536551
Borderline personality disorder 27.75 15.93 20 174986 907 79568475
Self-injurious ideation 27.73 15.93 37 174969 3601 79565781
Bacteraemia 27.72 15.93 19 174987 32805 79536577
Blood albumin decreased 27.63 15.93 116 174890 24127 79545255
Loss of consciousness 27.62 15.93 520 174486 167423 79401959
Defect conduction intraventricular 27.59 15.93 16 174990 497 79568885
Hypoacusis 27.46 15.93 16 174990 30134 79539248
Therapeutic product effect incomplete 27.36 15.93 190 174816 141455 79427927
Oropharyngeal pain 27.35 15.93 135 174871 109218 79460164
Lymphocytosis 27.34 15.93 42 174964 4651 79564731
Tonic clonic movements 27.13 15.93 29 174977 2235 79567147
Prostate cancer 27.12 15.93 20 174986 33248 79536134
Purpura 27.12 15.93 5 175001 19522 79549860
Bone marrow failure 27 15.93 44 174962 51063 79518319
Aortic dilatation 26.80 15.93 26 174980 1786 79567596
Microcytosis 26.75 15.93 14 174992 354 79569028
Testicular atrophy 26.64 15.93 14 174992 357 79569025
Brain injury 26.59 15.93 70 174936 11447 79557935
Thrombocytosis 26.33 15.93 58 174948 8468 79560914
Acute myocardial infarction 26.33 15.93 84 174922 76952 79492430
Galactorrhoea 26.14 15.93 36 174970 3610 79565772
Photosensitivity reaction 26.14 15.93 7 174999 21120 79548262
Torticollis 25.87 15.93 29 174977 2358 79567024
Coma 25.87 15.93 336 174670 100313 79469069
Retrograde ejaculation 25.84 15.93 13 174993 302 79569080
Flank pain 25.66 15.93 6 175000 19838 79549544
Eye swelling 25.63 15.93 13 174993 26455 79542927
Reduced facial expression 25.63 15.93 31 174975 2734 79566648
Non-Hodgkin's lymphoma unspecified histology aggressive 25.62 15.93 5 175001 0 79569382
Blood bicarbonate decreased 25.51 15.93 43 174963 5148 79564234
Upper gastrointestinal haemorrhage 25.44 15.93 32 174974 41348 79528034
Drug level above therapeutic 25.44 15.93 58 174948 8665 79560717
Sedation complication 25.42 15.93 84 174922 15585 79553797
Tangentiality 25.42 15.93 11 174995 179 79569203
Blood osmolarity decreased 25.34 15.93 22 174984 1309 79568073
Oral candidiasis 25.22 15.93 17 174989 29611 79539771
Ventricular fibrillation 25.00 15.93 20 174986 31906 79537476
Muscle spasticity 24.95 15.93 8 174998 21467 79547915
Anticholinergic syndrome 24.92 15.93 35 174971 3576 79565806
Eosinophilic myocarditis 24.90 15.93 21 174985 1201 79568181
Skin reaction 24.87 15.93 3 175003 16065 79553317
Blood pressure diastolic decreased 24.85 15.93 18 174988 30198 79539184
Cardiomegaly 24.71 15.93 119 174887 26233 79543149
Haemodialysis 24.49 15.93 5 175001 18163 79551219
Cogwheel rigidity 24.45 15.93 32 174974 3056 79566326
Stress 24.38 15.93 91 174915 79521 79489861
Gait disturbance 24.34 15.93 315 174691 207191 79362191
Syncope 24.28 15.93 264 174742 179185 79390197
Psychotic behaviour 24.25 15.93 20 174986 1109 79568273
Red cell distribution width decreased 24.24 15.93 26 174980 2012 79567370
Blood urea nitrogen/creatinine ratio decreased 24.22 15.93 9 174997 96 79569286
Excessive masturbation 24.22 15.93 9 174997 96 79569286
Tobacco user 24.16 15.93 17 174989 742 79568640
Creatinine renal clearance decreased 24.07 15.93 6 175000 18996 79550386
Chronic hepatitis C 24.04 15.93 16 174990 637 79568745
Disturbance in attention 23.87 15.93 192 174814 50609 79518773
Inflammation 23.87 15.93 115 174891 93638 79475744
Testicular cancer metastatic 23.66 15.93 8 174998 63 79569319
Eczema 23.63 15.93 33 174973 40785 79528597
Systolic dysfunction 23.58 15.93 35 174971 3760 79565622
Right ventricular failure 23.58 15.93 11 174995 23486 79545896
Spinal pain 23.52 15.93 3 175003 15389 79553993
Neurotoxicity 23.48 15.93 22 174984 32496 79536886
Proteinuria 23.46 15.93 22 174984 32480 79536902
Soliloquy 23.45 15.93 16 174990 664 79568718
Hepatic function abnormal 23.42 15.93 82 174924 73025 79496357
Pregnancy 23.41 15.93 15 174991 26836 79542546
Antisocial personality disorder 23.34 15.93 8 174998 66 79569316
Staphylococcal infection 23.28 15.93 59 174947 58236 79511146
Photophobia 23.23 15.93 8 174998 20520 79548862
Device malfunction 23.18 15.93 9 174997 21439 79547943
Polyneuropathy 23.18 15.93 12 174994 24139 79545243
Ecchymosis 23.15 15.93 3 175003 15203 79554179
Grandiosity 23.11 15.93 15 174991 572 79568810
Oligospermia 23.08 15.93 7 174999 37 79569345
Blood urine present 22.92 15.93 9 174997 21288 79548094
Transient ischaemic attack 22.90 15.93 51 174955 52644 79516738
Parkinson's disease 22.90 15.93 23 174983 1648 79567734
Blood bilirubin increased 22.79 15.93 72 174934 66160 79503222
Heart rate increased 22.76 15.93 382 174624 120342 79449040
Rash macular 22.76 15.93 18 174988 28881 79540501
Trifascicular block 22.66 15.93 10 174996 171 79569211
Left ventricular dilatation 22.60 15.93 19 174987 1082 79568300
Drowning 22.52 15.93 17 174989 828 79568554
Blood creatine phosphokinase decreased 22.51 15.93 18 174988 955 79568427
Dementia with Lewy bodies 22.50 15.93 17 174989 829 79568553
Myelodysplastic syndrome 22.48 15.93 20 174986 30281 79539101
Palliative care 22.48 15.93 18 174988 957 79568425
Dermatitis allergic 22.44 15.93 6 175000 18124 79551258
Skin necrosis 22.36 15.93 6 175000 18081 79551301
Tension 22.34 15.93 37 174969 4367 79565015
Sinus rhythm 22.29 15.93 17 174989 841 79568541
Granulocytosis 22.18 15.93 12 174994 325 79569057
Diet refusal 22.06 15.93 17 174989 854 79568528
Abnormal clotting factor 22.04 15.93 10 174996 183 79569199
Full blood count decreased 22.02 15.93 16 174990 26803 79542579
Electrocardiogram ST-T change 21.78 15.93 22 174984 1587 79567795
Chest pain 21.76 15.93 463 174543 281841 79287541
Globulin abnormal 21.69 15.93 5 175001 6 79569376
Cervix cancer metastatic 21.69 15.93 5 175001 6 79569376
Poor personal hygiene 21.66 15.93 14 174992 530 79568852
Petechiae 21.62 15.93 9 174997 20556 79548826
Chromaturia 21.61 15.93 15 174991 25731 79543651
Water intoxication 21.58 15.93 16 174990 758 79568624
Stoma site discomfort 21.58 15.93 9 174997 133 79569249
Face oedema 21.56 15.93 18 174988 28118 79541264
Somatic dysfunction 21.55 15.93 6 175000 22 79569360
Loss of libido 21.53 15.93 28 174978 2657 79566725
Haematotoxicity 21.49 15.93 4 175002 15515 79553867
Sudden cardiac death 21.45 15.93 40 174966 5185 79564197
Blood creatinine increased 21.43 15.93 227 174779 154830 79414552
Gender dysphoria 21.42 15.93 7 174999 49 79569333
Intestinal infarction 21.33 15.93 20 174986 1316 79568066
Abortion spontaneous 21.26 15.93 20 174986 29487 79539895
Learning disability 21.23 15.93 10 174996 200 79569182
Drop attacks 21.23 15.93 18 174988 1037 79568345
Red blood cell elliptocytes present 21.14 15.93 10 174996 202 79569180
Increased appetite 21.05 15.93 66 174940 11912 79557470
Hyperosmolar state 21.05 15.93 15 174991 668 79568714
Acute coronary syndrome 21.04 15.93 10 174996 21123 79548259
Eye movement disorder 20.90 15.93 51 174955 7960 79561422
Gingival bleeding 20.89 15.93 5 175001 16271 79553111
Pharyngeal oedema 20.88 15.93 5 175001 16267 79553115
Deafness 20.87 15.93 10 174996 21027 79548355
Influenza B virus test positive 20.77 15.93 12 174994 370 79569012
Flat affect 20.77 15.93 24 174982 2017 79567365
White blood cell disorder 20.64 15.93 30 174976 3162 79566220
Vasculitis 20.58 15.93 15 174991 25087 79544295
Sputum discoloured 20.58 15.93 11 174995 21732 79547650
Poverty of speech 20.54 15.93 14 174992 580 79568802
Blood folate abnormal 20.50 15.93 4 175002 0 79569382
Cholinergic rebound syndrome 20.50 15.93 4 175002 0 79569382
Electrocardiogram QT shortened 20.49 15.93 10 174996 217 79569165
Laryngitis 20.44 15.93 5 175001 16034 79553348
Dyslipidaemia 20.35 15.93 64 174942 11569 79557813
Rib fracture 20.07 15.93 19 174987 27928 79541454
Adjusted calcium increased 19.99 15.93 7 174999 62 79569320
Physical assault 19.95 15.93 21 174985 1590 79567792
Transferrin saturation decreased 19.94 15.93 18 174988 1128 79568254
Crying 19.92 15.93 13 174993 23030 79546352
Autism spectrum disorder 19.86 15.93 18 174988 1134 79568248
Enterococcal infection 19.73 15.93 5 175001 15655 79553727
Cardiac arrest 19.73 15.93 506 174500 171590 79397792
Product dispensing error 19.67 15.93 69 174937 13194 79556188
Subdural haematoma 19.65 15.93 24 174982 31410 79537972
Somatic symptom disorder 19.64 15.93 26 174980 2511 79566871
Blood test abnormal 19.61 15.93 84 174922 17626 79551756
Tenderness 19.55 15.93 14 174992 23628 79545754
Influenza 19.46 15.93 186 174820 129420 79439962
Necrotising colitis 19.42 15.93 17 174989 1023 79568359
Non-high-density lipoprotein cholesterol increased 19.31 15.93 11 174995 330 79569052
Premature delivery 19.27 15.93 14 174992 23453 79545929
Posturing 19.24 15.93 17 174989 1036 79568346
Vitamin B complex deficiency 19.20 15.93 15 174991 769 79568613
Illness anxiety disorder 19.17 15.93 10 174996 251 79569131
Dermatitis bullous 19.04 15.93 4 175002 14241 79555141
Amylase decreased 18.98 15.93 9 174997 183 79569199
Electrocardiogram ST segment abnormal 18.89 15.93 20 174986 1525 79567857
Cerebrovascular accident 18.86 15.93 234 174772 155058 79414324
Disability 18.81 15.93 7 174999 17113 79552269
Hyperthermia 18.79 15.93 84 174922 17953 79551429
Blood cholesterol decreased 18.77 15.93 21 174985 1704 79567678
Life support 18.69 15.93 12 174994 449 79568933
Stoma site extravasation 18.62 15.93 11 174995 354 79569028
Cardiac septal hypertrophy 18.58 15.93 10 174996 268 79569114
Lymphocyte morphology abnormal 18.58 15.93 16 174990 942 79568440
Aplastic anaemia 18.56 15.93 8 174998 17897 79551485
Wrong patient 18.54 15.93 11 174995 357 79569025
Spinal osteoarthritis 18.47 15.93 7 174999 16920 79552462
Autonomic nervous system imbalance 18.45 15.93 35 174971 4595 79564787
Balance disorder 18.41 15.93 134 174872 98723 79470659
Hemiplegia 18.38 15.93 5 175001 14934 79554448
Delusional perception 18.21 15.93 11 174995 369 79569013
Taste disorder 18.19 15.93 6 175000 15817 79553565
Contraindicated product administered 18.16 15.93 240 174766 157298 79412084
Blood bicarbonate increased 18.10 15.93 18 174988 1274 79568108
Drug dependence 18.10 15.93 39 174967 40730 79528652
Stoma site pain 18.05 15.93 19 174987 1439 79567943
Norepinephrine increased 18.02 15.93 7 174999 85 79569297
Pulmonary haemorrhage 17.97 15.93 5 175001 14712 79554670
Leukaemia 17.95 15.93 40 174966 5885 79563497
Paraneoplastic rash 17.88 15.93 7 174999 87 79569295
Conjunctivitis 17.87 15.93 18 174988 25697 79543685
Memory impairment 17.79 15.93 158 174848 111576 79457806
Cognitive disorder 17.78 15.93 233 174773 69693 79499689
Compensatory sweating 17.67 15.93 6 175000 48 79569334
Lymphoedema 17.63 15.93 3 175003 12410 79556972
Head discomfort 17.57 15.93 5 175001 14497 79554885
Irritability 17.47 15.93 152 174854 40992 79528390
Myocardial necrosis marker increased 17.45 15.93 28 174978 3218 79566164
Small intestinal obstruction 17.42 15.93 111 174895 27161 79542221
Viral myocarditis 17.42 15.93 12 174994 506 79568876
Resting tremor 17.38 15.93 19 174987 1502 79567880
Oliguria 17.37 15.93 7 174999 16302 79553080
Gastritis 17.35 15.93 51 174955 47942 79521440
Rhinitis allergic 17.34 15.93 3 175003 12266 79557116
Left atrial enlargement 17.30 15.93 17 174989 1186 79568196
Blood creatine decreased 17.29 15.93 10 174996 309 79569073
Drug level decreased 17.27 15.93 70 174936 14332 79555050
Ankylosing spondylitis 17.22 15.93 3 175003 12202 79557180
Atonic seizures 17.18 15.93 14 174992 763 79568619
Anaemia 17.12 15.93 800 174206 444215 79125167
Illness 17.12 15.93 49 174957 46462 79522920
Diarrhoea haemorrhagic 17.12 15.93 4 175002 13230 79556152
Alcohol problem 16.95 15.93 6 175000 55 79569327
Ear infection 16.95 15.93 31 174975 34401 79534981
Endotracheal intubation 16.89 15.93 34 174972 4663 79564719
Groin pain 16.82 15.93 4 175002 13076 79556306
Needle issue 16.80 15.93 4 175002 13064 79556318
Thyroid disorder 16.79 15.93 5 175001 14074 79555308
Skin cancer 16.78 15.93 6 175000 15034 79554348
Thalassaemia 16.76 15.93 6 175000 57 79569325
Peripheral sensory neuropathy 16.74 15.93 4 175002 13029 79556353
Oropharyngeal spasm 16.73 15.93 11 174995 429 79568953
Substance abuse 16.69 15.93 56 174950 10470 79558912
Bladder trabeculation 16.67 15.93 6 175000 58 79569324
Peripheral venous disease 16.67 15.93 7 174999 15902 79553480
Carditis 16.63 15.93 8 174998 168 79569214
Fistula 16.56 15.93 4 175002 12936 79556446
Acute respiratory distress syndrome 16.54 15.93 46 174960 44021 79525361
Diverticulum 16.52 15.93 6 175000 14890 79554492
Pseudomonas infection 16.48 15.93 13 174993 20890 79548492
Wound infection 16.44 15.93 17 174989 23974 79545408
Complication associated with device 16.34 15.93 9 174997 17487 79551895
Staphylococcal sepsis 16.22 15.93 6 175000 14720 79554662
Mental status changes 16.15 15.93 221 174785 66738 79502644
Sperm concentration decreased 16.06 15.93 6 175000 65 79569317
Cardiac failure 16.03 15.93 241 174765 154601 79414781
Ovarian cyst 16.02 15.93 4 175002 12651 79556731
Bipolar disorder 15.95 15.93 45 174961 7662 79561720

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC N05AH02 NERVOUS SYSTEM
PSYCHOLEPTICS
ANTIPSYCHOTICS
Diazepines, oxazepines, thiazepines and oxepines
FDA EPC N0000175430 Atypical Antipsychotic
CHEBI has role CHEBI:35703 Xenobiotic
CHEBI has role CHEBI:37887 adrenergic blockers
CHEBI has role CHEBI:37956 antihistamines
CHEBI has role CHEBI:48279 serotonin antagonists
CHEBI has role CHEBI:48561 dopaminergic antagonists
CHEBI has role CHEBI:48876 muscarinic antagonists
CHEBI has role CHEBI:65191 atypical antipsychotic agent
CHEBI has role CHEBI:65259 GABA antagonists
CHEBI has role CHEBI:76779 post-proline endopeptidase inhibitors
CHEBI has role CHEBI:78298 environmental contaminants
MeSH PA D014150 Antipsychotic Agents
MeSH PA D002491 Central Nervous System Agents
MeSH PA D002492 Central Nervous System Depressants
MeSH PA D018682 GABA Agents
MeSH PA D018756 GABA Antagonists
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D011619 Psychotropic Drugs
MeSH PA D018490 Serotonin Agents
MeSH PA D012702 Serotonin Antagonists
MeSH PA D014149 Tranquilizing Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Treatment-Resistant Schizophrenia indication
Suicidal Behavior in Schizophrenia indication
Suicidal Behavior in Schizoaffective Disorder indication
Bipolar disorder in remission off-label use 85248005
Bipolar affective disorder, current episode manic off-label use 191618007
Sinus tachycardia contraindication 11092001
Constipation contraindication 14760008 DOID:2089
Neuroleptic malignant syndrome contraindication 15244003 DOID:14464
Senile dementia contraindication 15662003
Agranulocytosis contraindication 17182001 DOID:12987
Lowered convulsive threshold contraindication 19260006
Orthostatic hypotension contraindication 28651003
Dehydration contraindication 34095006
Alcohol-induced psychosis contraindication 42344001 DOID:252
Fecal impaction contraindication 44635007
Conduction disorder of the heart contraindication 44808001
Low blood pressure contraindication 45007003
Drug-induced neutropenia contraindication 47318007
Myocarditis contraindication 50920009 DOID:820
Paralytic ileus contraindication 55525008 DOID:8442
Hyperlipidemia contraindication 55822004 DOID:1168
Cerebrovascular disease contraindication 62914000 DOID:6713
Diabetes mellitus contraindication 73211009 DOID:9351
Hyperglycemia contraindication 80394007 DOID:4195
Decreased respiratory function contraindication 80954004
Leukopenia contraindication 84828003 DOID:615
Tardive dyskinesia contraindication 102449007
Deep venous thrombosis contraindication 128053003
Seizure disorder contraindication 128613002
Liver function tests abnormal contraindication 166603001
Primary dilated cardiomyopathy contraindication 195021004
Cerebrovascular accident contraindication 230690007
Pulmonary thromboembolism contraindication 233935004
Disease of liver contraindication 235856003 DOID:409
Metabolic syndrome X contraindication 237602007 DOID:14221
Benign prostatic hyperplasia contraindication 266569009
Retention of urine contraindication 267064002
Syncope contraindication 271594007
Neutropenic disorder contraindication 303011007 DOID:1227
Bone marrow depression contraindication 307762000
Coma contraindication 371632003
At risk for aspiration contraindication 371736008
Eosinophil count raised contraindication 386789004
Angle-closure glaucoma contraindication 392291006 DOID:13550
Breastfeeding (mother) contraindication 413712001
Disorder of coronary artery contraindication 414024009
Obesity contraindication 414916001 DOID:9970
Central nervous system depression contraindication 418072004
Gastrointestinal hypomotility contraindication 421807004
Uncontrolled Epilepsy contraindication
Substance Overdose contraindication
Neoplastic Myeloproliferative Disorders contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 7.59 Basic
pKa2 4.17 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
D(2) dopamine receptor GPCR ANTAGONIST Ki 6.86 WOMBAT-PK CHEMBL
5-hydroxytryptamine receptor 2A GPCR ANTAGONIST Ki 8.30 WOMBAT-PK CHEMBL
Beta-1 adrenergic receptor GPCR Ki 5.30 PDSP
Beta-2 adrenergic receptor GPCR Ki 5.78 PDSP
D(1A) dopamine receptor GPCR Ki 6.89 WOMBAT-PK
Alpha-2A adrenergic receptor GPCR Ki 7.15 WOMBAT-PK
Sigma non-opioid intracellular receptor 1 Membrane receptor IC50 5.20 WOMBAT-PK
Potassium voltage-gated channel subfamily H member 2 Ion channel IC50 6.60 WOMBAT-PK
Sodium-dependent serotonin transporter Transporter Ki 5.41 CHEMBL
Sodium-dependent noradrenaline transporter Transporter Ki 5.83 WOMBAT-PK
5-hydroxytryptamine receptor 1A GPCR Ki 8.20 CHEMBL
5-hydroxytryptamine receptor 2B GPCR Ki 8.26 WOMBAT-PK
5-hydroxytryptamine receptor 2C GPCR Ki 8.05 WOMBAT-PK
5-hydroxytryptamine receptor 6 GPCR Ki 7.95 WOMBAT-PK
5-hydroxytryptamine receptor 7 GPCR Ki 7.78 WOMBAT-PK
Alpha-1A adrenergic receptor GPCR Ki 8.10 WOMBAT-PK
Alpha-2B adrenergic receptor GPCR Ki 7.42 WOMBAT-PK
D(3) dopamine receptor GPCR ANTAGONIST Ki 6.59 WOMBAT-PK
D(1B) dopamine receptor GPCR Ki 6.59 WOMBAT-PK
Histamine H1 receptor GPCR Ki 9.20 WOMBAT-PK
Histamine H2 receptor GPCR Ki 6.82 WOMBAT-PK
Histamine H4 receptor GPCR Ki 8.23 WOMBAT-PK
Muscarinic acetylcholine receptor M1 GPCR IC50 8.18 WOMBAT-PK
Muscarinic acetylcholine receptor M2 GPCR Ki 7.30 WOMBAT-PK
Muscarinic acetylcholine receptor M5 GPCR Ki 7.79 WOMBAT-PK
Aldehyde oxidase Enzyme IC50 5.36 WOMBAT-PK
5-hydroxytryptamine receptor 1B GPCR AGONIST Ki 6.20 IUPHAR
5-hydroxytryptamine receptor 1D GPCR AGONIST Ki 6.40 IUPHAR
Alpha-2C adrenergic receptor GPCR Ki 8.54 WOMBAT-PK
Adenosine receptor A3 GPCR IC50 6.81 CHEMBL
D(4) dopamine receptor GPCR ANTAGONIST Ki 7.52 WOMBAT-PK
Alpha-1D adrenergic receptor GPCR ANTAGONIST Ki 7.70 IUPHAR
5-hydroxytryptamine receptor 3A Ion channel Ki 7.28 WOMBAT-PK
Alpha-1B adrenergic receptor GPCR Ki 7.98 WOMBAT-PK
UDP-glucuronosyltransferase 1-4 Enzyme app Km 4.21 WOMBAT-PK
5-hydroxytryptamine receptor 5A GPCR Ki 6 CHEMBL
5-hydroxytryptamine receptor 1F GPCR AGONIST Ki 6.90 IUPHAR
5-hydroxytryptamine receptor 1E GPCR AGONIST Ki 6.40 IUPHAR
Histone H1.0 Nuclear other Ki 9 CHEMBL
Muscarinic acetylcholine receptor M3 GPCR Ki 7.59 WOMBAT-PK
Calmodulin-1 Cytosolic other IC50 4.70 CHEMBL
Muscarinic acetylcholine receptor M4 GPCR EC50 7.22 WOMBAT-PK
Alpha-1B adrenergic receptor GPCR Ki 8.45 DRUG MATRIX
5-hydroxytryptamine receptor 1B GPCR IC50 5.60 CHEMBL
Alpha-1A adrenergic receptor GPCR Ki 7.66 CHEMBL
Histamine H1 receptor GPCR Ki 8.42 CHEMBL
Muscarinic acetylcholine receptor M2 GPCR Ki 7.34 CHEMBL
Muscarinic acetylcholine receptor M1 GPCR Ki 8.68 CHEMBL
D(2) dopamine receptor GPCR Ki 7.47 CHEMBL
5-hydroxytryptamine receptor 1A GPCR Ki 7.41 CHEMBL
5-hydroxytryptamine receptor 2A GPCR Ki 8.22 CHEMBL
Transporter Transporter Ki 6.16 CHEMBL
5-hydroxytryptamine receptor 7 GPCR Ki 8.20 CHEMBL
5-hydroxytryptamine receptor 7 GPCR ANTAGONIST Ki 7.40 IUPHAR
D(1A) dopamine receptor GPCR Ki 6.38 CHEMBL
Beta-1 adrenergic receptor GPCR Ki 4.59 CHEMBL
D(1A) dopamine receptor GPCR Ki 7.37 CHEMBL
D(2) dopamine receptor GPCR Ki 6.16 CHEMBL
Alpha-2A adrenergic receptor GPCR Ki 7.72 CHEMBL
D(2) dopamine receptor GPCR IC50 6.54 CHEMBL
5-hydroxytryptamine receptor 2C GPCR Ki 8.10 CHEMBL
5-hydroxytryptamine receptor 1A GPCR IC50 5.70 CHEMBL
Alpha-1A adrenergic receptor GPCR IC50 6.80 CHEMBL
Histamine H1 receptor GPCR Ki 8.54 CHEMBL
D(3) dopamine receptor GPCR Ki 6.79 CHEMBL
D(4) dopamine receptor GPCR Ki 8.05 CHEMBL
D(2) dopamine receptor GPCR Ki 6.60 CHEMBL
5-hydroxytryptamine receptor 2A GPCR IC50 8.52 CHEMBL
Histamine H3 receptor GPCR ANTAGONIST Ki 5.80 IUPHAR
5-hydroxytryptamine receptor 3A Ion channel Ki 7.49 CHEMBL
5-hydroxytryptamine receptor 6 GPCR ANTAGONIST Ki 8.40 IUPHAR
D(1A) dopamine receptor GPCR Ki 6.38 CHEMBL
Transporter Transporter Ki 6.41 CHEMBL
D(3) dopamine receptor GPCR Ki 6.33 CHEMBL
Histamine H4 receptor GPCR ANTAGONIST Ki 5.50 IUPHAR
Histamine H4 receptor GPCR ANTAGONIST Ki 5.70 IUPHAR
Serotonin 3 (5-HT3) receptor Ion channel Ki 7.28 CHEMBL
Muscarinic acetylcholine receptor GPCR Ki 7.60 CHEMBL
Serotonin 1 (5-HT1) receptor GPCR Ki 6.68 CHEMBL
Adrenergic receptor alpha-2 GPCR Ki 7.24 CHEMBL
Dopamine receptor GPCR IC50 6.74 CHEMBL
Dopamine receptor GPCR Ki 6.49 CHEMBL
Serotonin 2 (5-HT2) receptor GPCR Ki 8.74 CHEMBL
Adenylate cyclase Enzyme IC50 6.85 CHEMBL
Serotonin 2 (5-HT2) receptor GPCR IC50 7.55 CHEMBL
5-hydroxytryptamine receptor 5A GPCR ANTAGONIST Ki 5.30 IUPHAR
Calmodulin Cytosolic other Kd 4.21 CHEMBL

External reference:

IDSource
4019488 VUID
N0000147608 NUI
D00283 KEGG_DRUG
216102 RXNORM
4019488 VANDF
4024939 VANDF
4036908 VANDF
4037056 VANDF
4037345 VANDF
4040180 VANDF
C0009079 UMLSCUI
CHEBI:3766 CHEBI
CHEMBL42 ChEMBL_ID
CHEMBL538973 ChEMBL_ID
DB00363 DRUGBANK_ID
D003024 MESH_DESCRIPTOR_UI
135398737 PUBCHEM_CID
38 IUPHAR_LIGAND_ID
2612 INN_ID
J60AR2IKIC UNII
11496 MMSL
420 MMSL
4484 MMSL
50904 MMSL
d00199 MMSL
003526 NDDF
387568001 SNOMEDCT_US
96221003 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-3010 TABLET, ORALLY DISINTEGRATING 100 mg ORAL NDA authorized generic 28 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-3010 TABLET, ORALLY DISINTEGRATING 100 mg ORAL NDA authorized generic 28 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-3011 TABLET, ORALLY DISINTEGRATING 12.50 mg ORAL NDA authorized generic 28 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-3011 TABLET, ORALLY DISINTEGRATING 12.50 mg ORAL NDA authorized generic 28 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-3012 TABLET, ORALLY DISINTEGRATING 25 mg ORAL NDA authorized generic 28 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-3012 TABLET, ORALLY DISINTEGRATING 25 mg ORAL NDA authorized generic 28 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-3086 TABLET, ORALLY DISINTEGRATING 150 mg ORAL NDA authorized generic 28 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-3086 TABLET, ORALLY DISINTEGRATING 150 mg ORAL NDA authorized generic 28 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-3087 TABLET, ORALLY DISINTEGRATING 200 mg ORAL NDA authorized generic 28 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-3087 TABLET, ORALLY DISINTEGRATING 200 mg ORAL NDA authorized generic 28 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-4359 TABLET 25 mg ORAL ANDA 27 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-4359 TABLET 25 mg ORAL ANDA 27 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-4359 TABLET 25 mg ORAL ANDA 27 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-4404 TABLET 50 mg ORAL ANDA 27 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-4404 TABLET 50 mg ORAL ANDA 27 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-4404 TABLET 50 mg ORAL ANDA 27 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-4405 TABLET 200 mg ORAL ANDA 27 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-4405 TABLET 200 mg ORAL ANDA 27 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-4405 TABLET 200 mg ORAL ANDA 27 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-5376 TABLET, ORALLY DISINTEGRATING 150 mg ORAL ANDA 28 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-5376 TABLET, ORALLY DISINTEGRATING 150 mg ORAL ANDA 28 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-5377 TABLET, ORALLY DISINTEGRATING 200 mg ORAL ANDA 28 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-5377 TABLET, ORALLY DISINTEGRATING 200 mg ORAL ANDA 28 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-5416 TABLET, ORALLY DISINTEGRATING 12.50 mg ORAL ANDA 28 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-5416 TABLET, ORALLY DISINTEGRATING 12.50 mg ORAL ANDA 28 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-5417 TABLET, ORALLY DISINTEGRATING 25 mg ORAL ANDA 28 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-5417 TABLET, ORALLY DISINTEGRATING 25 mg ORAL ANDA 28 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-5419 TABLET, ORALLY DISINTEGRATING 100 mg ORAL ANDA 28 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-5419 TABLET, ORALLY DISINTEGRATING 100 mg ORAL ANDA 28 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-7772 TABLET 100 mg ORAL ANDA 27 sections